Assessment of the analgesic action of opioid agonist-antagonists in the rabbit
Article first published online: 28 JUN 2008
Veterinary Anaesthesia and Analgesia
Volume 17, Issue 1, pages 24–29, January 1990
How to Cite
Flecknell, P. A. and Liles, J. H. (1990), Assessment of the analgesic action of opioid agonist-antagonists in the rabbit. Veterinary Anaesthesia and Analgesia, 17: 24–29. doi: 10.1111/j.1467-2995.1990.tb00384.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
The analgesic actions of buprenorphine, butorphanol, nalbuphine and pentazocine were assessed in the rabbit by analgesiometry using a thermal stimulus. All four compounds produced effective analgesia without causing serious respiratory depression. Increased dose rates of buprenorphine, butorphanol and nalbuphine produced only a minor increase in the maximum degree of analgesia attained. At the highest dose rates of nalbuphine and butorphanol which were assessed there appeared to be a reduction in the degree of analgesia and its duration of action whereas increased dose rates of buprenorphine produced progressively longer periods of analgesia (0.0075mg/kg - 150min; 0.03mg/kg -660min; 0.3mg/kg - >780 min).
The results indicate that these opioids can be used safely to provide pain relief in rabbits, provided that excessively high dose rates of nalbuphine and butorphanol are avoided.