Medetomidine and dexmedetomidine: a review of cardiovascular effects and antinociceptive properties in the dog

Authors

  • Joanna C Murrell BVSc, PhD, Diploma ECVA,

    1. Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, the Netherlands
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  • Ludo J Hellebrekers DVM, PhD, Diploma ECVA

    1. Department of Clinical Sciences of Companion Animals and Department of Equine Sciences, University of Utrecht, Utrecht, the Netherlands
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Joanna C Murrell, Institute of Veterinary, Animal and Biomedical Sciences, College of Sciences, Massey University, Private Bag 11222, Palmerston North, New Zealand. E-mail: j.c.murrell@massey.ac.nz

Abstract

Alpha2-adrenoreceptor agonists (α2-agonists) are commonly used in small animal anaesthesia for their potent sedative and analgesic properties, although concerns about their cardiovascular effects have prevented their full adoption into veterinary practice. Research into alpha2 adrenoreceptor agonists and their clinical use is extensive, therefore this review focuses on the use of dexmedetomidine and medetomidine in dogs. Emphasis is given to the cardiovascular effects and antinociceptive action of these agents.

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