Pharmacokinetics of hydromorphone hydrochloride in healthy dogs
Article first published online: 18 FEB 2008
© 2008 The Authors. Journal compilation © 2008 Association of Veterinary Anaesthetists
Veterinary Anaesthesia and Analgesia
Volume 35, Issue 3, pages 256–264, May 2008
How to Cite
KuKanich, B., Hogan, B. K., Krugner-Higby, L. A. and Smith, L. J. (2008), Pharmacokinetics of hydromorphone hydrochloride in healthy dogs. Veterinary Anaesthesia and Analgesia, 35: 256–264. doi: 10.1111/j.1467-2995.2007.00379.x
- Issue published online: 18 FEB 2008
- Article first published online: 18 FEB 2008
- Received 7 February 2007; accepted 20 April 2007.
- constant rate infusion;
Objective To assess the pharmacokinetics of hydromorphone administered intravenously (IV) or subcutaneously (SC) to dogs.
Study design Randomized experimental trial.
Animals Seven healthy male neutered Beagles aged 12.13 ± 1.2 months and weighing 11.72 ± 1.10 kg.
Methods The study was a randomized Latin square block design. Dogs were randomly assigned to receive hydromorphone hydrochloride 0.1 mg kg−1 or 0.5 mg kg−1 IV (n = 4 dogs) or 0.1 mg kg−1 (n = 6) or 0.5 mg kg−1 (n = 5) SC on separate occasions with a minimum 14-day washout between experiments. Blood was sampled via a vascular access port at serial intervals after drug administration. Serum was analyzed by mass spectrometry. Pharmacokinetic parameters were determined with computer software.
Results Serum concentrations of hydromorphone decreased quickly after both routes of administration of either dose. The serum half-life, clearance, and volume of distribution after IV hydromorphone at 0.1 mg kg−1 were 0.57 hours (geometric mean), 106.28 mL minute−1 kg−1, and 5.35 L kg−1, and at 0.5 mg kg−1 were 1.00 hour, 60.30 mL minute−1 kg−1, and 5.23 L kg−1, respectively. The serum half-life after SC hydromorphone at 0.1 mg kg−1 and 0.5 mg kg−1 was 0.66 hours and 1.11 hours, respectively.
Conclusions and clinical relevance Hydromorphone has a short half-life, suggesting that frequent dosing intervals are needed. Based on pharmacokinetic parameters calculated in this study, 0.1 mg kg−1 IV or SC q 2 hours or a constant rate infusion of hydromorphone at 0.03 mg kg−1 hour−1 are suggested for future studies to assess the analgesic effect of hydromorphone.