Get access

Efficacy of tolfenamic acid and meloxicam in the control of postoperative pain following ovariohysterectomy in the cat

Authors

  • Javier Benito-de-la-Víbora DVM,

    1. Department of Animal Surgery and Medicine, Veterinary Faculty, University Complutense of Madrid, Madrid, Spain
    Search for more papers by this author
  • B Duncan X Lascelles BVSc, PhD, CertVA, MRCVS, DSAS(ST), Diplomate ECVS, Diplomate ACVS,

    1. Comparative Pain Research Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    Search for more papers by this author
  • Paloma García-Fernández DVM, Dr.Med.Vet,

    1. Department of Animal Surgery and Medicine, Veterinary Faculty, University Complutense of Madrid, Madrid, Spain
    Search for more papers by this author
  • Milagros Freire DVM,

    1. Department of Animal Surgery and Medicine, Veterinary Faculty, University Complutense of Madrid, Madrid, Spain
    Search for more papers by this author
  • Ignacio A Gómez de Segura DVM, Dr.Med.Vet, Diplomate ECVA, DECLAM

    1. Department of Animal Surgery and Medicine, Veterinary Faculty, University Complutense of Madrid, Madrid, Spain
    Search for more papers by this author

Ignacio A Gómez de Segura, Department of Animal Surgery and Medicine (Anestesiología), Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain. E-mail: iagsegura@vet.ucm.es

Summary

Objective  The hypothesis was that Visual Analog Scale (VAS) scores would be lower, and mechanical wound thresholds (MWT) higher, in cats receiving tolfenamic acid compared to those receiving placebo in the postoperative period following elective ovariohysterectomy.

Animals  Sixty-nine client-owned cats.

Methods  A prospective, randomized, blinded and placebo-controlled study was performed in cats which underwent ovariohysterectomy following preoperative tolfenamic acid, meloxicam, or placebo. A second dose of the same analgesic was administered 24 hours postoperatively. Assessments were made 1-hour before induction and 1, 2, 4, 6, 22, and 25 hours postoperatively. Pain was assessed by a blinded observer using Numerical Rating (NRS) and VAS scales. The MWT were measured using a force-measuring device. Group comparison was performed by using one-way anova and chi-squared test for qualitative and quantitative data, respectively, and a mixed model for repeated measurements (p < 0.05).

Results  Sixty-five cats were included in the study. There were no differences between groups at baseline. There was a treatment effect on the NRS scores at 6, 22 and 25 hours. The meloxicam group was less painful than controls at 6 and 22 hours; both treatment groups were less painful than controls at 25 hours. There were no differences between groups in VAS for pain or sedation. The number of animals receiving rescue analgesia did not differ between groups. There was a treatment effect on MWT; thresholds in both treatment groups were significantly higher than that observed in controls at all time points.

Conclusions  Preoperative tolfenamic acid or meloxicam reduced wound sensitivity following ovariohysterectomy in the cat.

Clinical relevance  Tolfenamic acid and meloxicam administered preoperatively provided a similar analgesic effect in the postoperative period lasting 24 hours. Mechanical thresholds may be a better way of evaluating postoperative analgesia provided by nonsteroidal anti-inflammatory drugs in cats.

Get access to the full text of this article

Ancillary