Alfaxalone in cyclodextrin for induction and maintenance of anaesthesia in ponies undergoing field castration
Version of Record online: 20 AUG 2009
© 2009 The Authors. Journal compilation © 2009 Association of Veterinary Anaesthetists
Veterinary Anaesthesia and Analgesia
Volume 36, Issue 5, pages 480–484, September 2009
How to Cite
Leece, E. A., Girard, N. M. and Maddern, K. (2009), Alfaxalone in cyclodextrin for induction and maintenance of anaesthesia in ponies undergoing field castration. Veterinary Anaesthesia and Analgesia, 36: 480–484. doi: 10.1111/j.1467-2995.2009.00479.x
- Issue online: 20 AUG 2009
- Version of Record online: 20 AUG 2009
- Received 16 February 2009; accepted 20 April 2009
Objective To evaluate the induction and maintenance of anaesthesia using alfaxalone following pre-anaesthetic medication with romifidine and butorphanol in ponies undergoing castration in the field.
Study design Prospective clinical study.
Animals Seventeen male ponies weighing 169 ± 29 kg.
Methods The ponies were sedated with romifidine and butorphanol intravenously (IV). Induction time was recorded following administration of alfaxalone 1 mg kg−1 and diazepam 0.02 mg kg−1 IV. If movement during surgery occurred, alfaxalone 0.2 mg kg−1 was administered IV. The quality of anaesthetic induction, and recovery were scored on a subjective scale of 1 (good) to 5 (poor). The number of attempts to attain sternal recumbency and standing, quality of recovery and times from induction to end of surgery, first head lift, sternal recumbency and standing were recorded.
Results Induction quality was good [median score (range) 1 (1–3)] with a mean ± SD time of 29 ± 6 seconds taken to achieve lateral recumbency. Ten ponies required incremental doses of alfaxalone during surgery. Mean times to the end of surgery, first head lift, sternal recumbency and standing were 26 ± 9 minutes, 31 ± 9 minutes, 33 ± 9 minutes and 34 ± 9 minutes respectively. The number of attempts to attain sternal recumbency was 1(1–1) and to attain standing was 1(1–2). Quality of recovery was good, with a recovery score of 1(1–2).
Conclusions and clinical relevance Alfaxalone provided smooth induction and recovery characteristics and was considered suitable for maintenance of anaesthesia for castration in ponies.