Combination of dexmedetomidine with buprenorphine enhances the antinociceptive effect to a thermal stimulus in the cat compared with either agent alone
Article first published online: 5 FEB 2010
© 2010 The Authors. Journal compilation © 2010 Association of Veterinary Anaesthetists
Veterinary Anaesthesia and Analgesia
Volume 37, Issue 2, pages 162–170, March 2010
How to Cite
Slingsby, L. S., Murrell, J. C. and Taylor, P. M. (2010), Combination of dexmedetomidine with buprenorphine enhances the antinociceptive effect to a thermal stimulus in the cat compared with either agent alone. Veterinary Anaesthesia and Analgesia, 37: 162–170. doi: 10.1111/j.1467-2995.2009.00519.x
- Issue published online: 5 FEB 2010
- Article first published online: 5 FEB 2010
- Received 1 June 2009; accepted 7 October 2009.
Objective To evaluate the sedative and antinociceptive effects of combinations of dexmedetomidine and buprenorphine in cats.
Study design Experimental randomized study.
Animals Twelve purpose-bred neutered domestic short-hair cats (4 male and 8 female) weighing 4.6 kg (range 3.7–5.5 kg) aged from 2 to 5 years.
Methods Six cats per group were administered buprenorphine (B) at 10 (B10) or 20 μg kg−1 (B20) or dexmedetomidine (D) at 20 (D20) or 40 μg kg−1 (D40) or a combination of B10/D20. A feline thermal nociceptive threshold testing device was used to evaluate the antinociceptive effects of the drugs before and up to 24 hours after drug treatment. Sedation was scored using a 100 mm visual analogue scale (VAS).
Results Thermal thresholds increased significantly after administration of all but D20. Area under the curve (AUC, hours °C) for the first 6 hours (mean ± SD) for B20 (281 ± 17.8) was significantly greater than B10 (260 ± 11.4), D20 (250 ± 7.9) and D40 (255 ± 11.4). The AUC for B10/D20 (273 ± 12.2) was significantly greater than D20 but not the other treatments. No sedation was seen after administration of B10 or B20 and maximal sedation was seen for all animals in the D40 and B10/D20 groups and most animals in the D20 group.
Conclusions D20 alone had the smallest analgesic effect; B10 alone provided no sedation but their combination gave good sedation with analgesia comparable with B20.
Clinical relevance This combination could be a useful multimodal sedative/analgesic regimen in cats.