Hemodynamic effects of butorphanol in desflurane-anesthetized dogs
Article first published online: 11 AUG 2011
© 2011 The Authors. Veterinary Anaesthesia and Analgesia. © 2011 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesiologists
Veterinary Anaesthesia and Analgesia
Volume 38, Issue 5, pages 467–474, September 2011
How to Cite
dos Santos, P. S. P., Nunes, N., de Souza, A. P., de Rezende, M. L., Nishimori, C. T., de Paula, D. P. and Ferro Lopes, P. C. (2011), Hemodynamic effects of butorphanol in desflurane-anesthetized dogs. Veterinary Anaesthesia and Analgesia, 38: 467–474. doi: 10.1111/j.1467-2995.2011.00644.x
- Issue published online: 11 AUG 2011
- Article first published online: 11 AUG 2011
- Received 7 August 2009; accepted 13 March 2010.
- anesthetic agent;
Objective To evaluate the effects of butorphanol on cardiopulmonary parameters in dogs anesthetized with desflurane and breathing spontaneously.
Study design Prospective, randomized experimental trial.
Animals Twenty dogs weighing 12 ± 3 kg.
Methods Animals were distributed into two groups: a control group (CG) and butorphanol group (BG). Propofol was used for induction and anesthesia was maintained with desflurane (10%). Forty minutes after induction, the dogs in the CG received sodium chloride 0.9% (0.05 mL kg−1 IM), and dogs in the BG received butorphanol (0.4 mg kg−1 IM). The first measurements of body temperature (BT), heart rate (HR), arterial pressures (AP), cardiac output (CO), cardiac index (CI), central venous pressure (CVP), stroke volume index (SVI), pulmonary arterial occlusion pressure (PAOP), mean pulmonary arterial pressure (mPAP), left ventricular stroke work (LVSW), systemic (SVR) and pulmonary (PVR) vascular resistances, respiratory rate (fR), and arterial oxygen (PaO2) and carbon dioxide (PaCO2) partial pressures were taken immediately before the administration of butorphanol or sodium chloride solution (T0) and then at 15-minute intervals (T15–T75).
Results In the BG, HR, AP, mPAP and SVR decreased significantly from T15 to T75 compared to baseline. fR was lower at T30 than at T0 in the BG. AP and fR were significantly lower than in the CG from T15 to T75. PVR was lower in the BG than in the CG at T30, while PaCO2 was higher compared with T0 from T30 to T75 in the BG and significantly higher than in the CG at T30 to T75.
Conclusions and clinical relevance At the studied dose, butorphanol caused hypotension and decreased ventilation during desflurane anesthesia in dogs. The hypotension (from 86 ± 10 to 64 ± 10 mmHg) is clinically relevant, despite the maintenance of cardiac index.