Measurement of respiratory system compliance and respiratory system resistance in healthy dogs undergoing general anaesthesia for elective orthopaedic procedures
Article first published online: 23 FEB 2013
© 2013 The Authors. Veterinary Anaesthesia and Analgesia © 2013 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia
Veterinary Anaesthesia and Analgesia
Volume 40, Issue 4, pages 382–389, July 2013
How to Cite
Bradbrook, C. A., Clark, L., Dugdale, A. H., Burford, J. and Mosing, M. (2013), Measurement of respiratory system compliance and respiratory system resistance in healthy dogs undergoing general anaesthesia for elective orthopaedic procedures. Veterinary Anaesthesia and Analgesia, 40: 382–389. doi: 10.1111/j.1467-2995.2012.00778.x
- Issue published online: 13 JUN 2013
- Article first published online: 23 FEB 2013
- Received 16 February 2012; accepted 13 May 2012.
- airway resistance;
- dynamic compliance;
- mechanical ventilation
Objective The aim of this study was to investigate normal values for the dynamic compliance of the respiratory system (Crs) and respiratory system resistance (Rrs) in mechanically ventilated anaesthetized dogs.
Study design Prospective clinical study.
Animals Forty healthy dogs undergoing elective orthopaedic surgery. Body weight was (mean ± SD) 26.8 ± 10.7 kg (range: 1.9–45.0 kg), age 4.7 ± 2.9 years (range: 0.1–10.6 years).
Methods Dogs were premedicated with acepromazine and methadone administered intramuscularly and anaesthesia induced with propofol intravenously. After endotracheal intubation the dog's lungs were connected to an appropriate breathing system depending on body weight and isoflurane in oxygen administered for maintenance of anaesthesia. The lungs were ventilated mechanically with variables set to maintain normocapnia (end-tidal carbon dioxide concentration 4.7–6.0 kPa). Peak inspiratory pressure, Crs, Rrs, tidal volume, respiratory rate and positive end-expiratory pressure were recorded at 5, 30, 60, 90 and 120 minutes after start of mechanical ventilation. Cardiovascular variables were recorded at time of collection of respiratory data.
Results General additive modeling revealed the following relationships: Crs = [0.895 × body weight (kg)] + 8.845 and Rrs = [−0.0966 × body weight (kg)] + 6.965. Body weight and endotracheal tube diameter were associated with Crs (p < 0.001 and p = 0.002 respectively) and Rrs (p = 0.017 and p = 0.002 respectively), body weight being linearly related to Crs and inversely to Rrs.
Conclusion and clinical relevance Body weight was linearly related to Crs while Rrs has an inverse linear relationship with body weight in mechanically ventilated dogs. The derived values of Crs and Rrs may be used for monitoring of lung function and ventilation in healthy dogs under anaesthesia.