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ABSTRACT This article reviews studies on the relation between social motives and susceptibility to physical illness The motives examined in the studies include power motivation and affiliation motivation and their related syndromes such as inhibited power and relaxed affiliation The subject populations include college students as well as adults Blood pressure, self-reports of illnesses, catecholamines, and parameters of immunologic functioning are among the indices of health outcomes investigated Taken together, these studies suggest that social motives may be importantly related to susceptibility to illness, that the power motive may be related to heightened susceptibility to illness, particularly when the person is under stress, whereas the affiliation motive may be related to diminished susceptibility to illness