SEARCH

SEARCH BY CITATION

References

  • Anonymous (2003) Meristem Therapeutics. (Other News To Note).(Brief Article). BioWorld International. 8, 9.
  • Aviezer, D., Brill-Almon, E., Shaaltiel, Y., Hashmueli, S., Bartfeld, D. Mizrachi, S., Liberman, Y., Freeman, A., Zimran, A. and Galun, E. (2009) A Plant-derived recombinant human glucocerebrosidase enzyme—A preclinical and phase I investigation. PLoS ONE, 4(3), e4792.
  • Baez, J., Russell, D. and Craig, J. (2000) Corn seed production of therapeutic proteins moves forward, one company’s experience. BioPharm. 3, 5054.
  • Basaran, P. and Rodríguez-Cerezo, E. (2008) Plant molecular farming: opportunities and challenges. Crit. Rev. Biotechnol. 28, 153172.
  • Bellini, M.H. and Bartolini, P. (1993) In vivo biassay for potency determination of human grwoth hormone in dwarf “little” mice. Endocrinology, 132, 21512155.
  • Bellini, M.H., Mathor, M.B., De Luca, M., Cancedda, R. and Bartolini, P. (1998) Ultrasensitive in vivo bioassay detects bioactive human growth hormone in transduced primary human keratinocytes. J. Endcrinol. Invest. 21, 16.
  • Berberich, S.A. and Devine, R.A. (2005a) US regulation of plant-made biopharmaceuticals: part 1. BioPharm Int’l. 18, 3846.
  • Berberich, S.A. and Devine, R.A. (2005b) US regulation of plant-made biopharmaceuticals: part 2. BioPharm Int’l. 18, 6871.
  • Boehm, R. (2007) Bioproduction of therapeutic proteins in the 21st century and the role of plants and plant cells as production platforms. Ann. NY Acad. Sci. 1102, 121134.
  • Boothe, J.G., Saponja, J.A. and Parmenter, D.L. (1997) Molecular farming in plants: oilseeds as vehicles for the production of pharmaceutical proteins. Drug Dev. Res. 42, 172181.
  • Boothe, J.G., Nykiforuk, C.L., Kuhlman, P.A., Whelan, H., Pollock, W.B.R., Clark, S., Yuan, S., Kumar, R., Murray, E.W., Visser, F., Martens, K., Wu, J., Pollock, E., Given, B., Szarka, S., Zaplachinski, S., Harry, I., Keon, R. and Moloney, M.M. (2009) Analytical characterization, safety and clinical bioequivalence of recombinant human insulin from transgenic plants. American Diabetes Association, 69th Scientific Sessions, Abstract 5-LB.
  • Bosch, D., Smal, D. and Krebbers, E. (1994) A trout growth hormone is expressed, correctly folded and partially glycosylated in the leaves but not the seeds of transgenic plants. Transgenic Res. 3, 304310.
  • Chance, R.E. and Frank, B.H. (1993) Research, development, production, and safety of biosynthetic human insulin. Diabetes Care, 16, 133142.
  • Conrad, U. and Fiedler, U. (1998) Compartment-specific accumulation of recombinant immunoglobulins in plant cells: an essential tool for antibody production and immunomodulation of physiological functions and pathogen activity. Plant Mol. Biol. 38, 101109.
  • Crosby, L. (2003) Commercial production of transgenic crops genetically engineered to produce pharmaceuticals. Biopharm Int’l. 16, 6067.
  • De Jaeger, G., Scheffer, S., Jacobs, A., Zambre, M., Zobell, O., Goossens, A., Depicker, A. and Angenon, G. (2002) Boosting heterologous protein production in transgenic dicotyledonous seeds using Phaseolus vulgaris regulatory sequences. Nat. Biotechnol. 12, 12651268.
  • Deckers, H.M., Van Rooijen, G., Boothe, J., Goll, J., Mahmoud, S. and Moloney, M.M. (2000) Uses of oil bodies United States Patent 6. 146,645.
  • DePalma, A. (2003) Is a green plant in your manufacturing future? Plant-made biopharmaceuticals are biotech’s next wave. BioPharm Int’l. 16, 2433.
  • Downing, W.L., Galpin, J.D., Clemens, S., Lauzon, S.M., Samuels, A.L., Pidkowich, M.S., Clarke, L.A. and  Kermode, A.R. (2006) Synthesis of enzymatically active human alpha-L-iduronidase in Arabidopsis cgl (complex-glycan-deficient) mutant seeds. Plant Biotechnol. J. 4, 169181.
  • EMBO Reports (2005) Molecular farming for new drugs and vaccines. EMBO 6, 593595.
  • EMEA (2008) Guideline on the quality of biological active substances produced by stable transgene expression in higher plants. Doc. Ref. EMEA/CHMP/BWP/48316/2006.
  • Evangelista, R.L., Kusnadi, A.R., Howard, J.A. and Nikolov, Z.L. (1998) Process and economic evaluation of the extraction and purification of recombinant ß-Glucuronidase from transgenic corn. Biotechnol. Prog. 14, 607614.
  • FDA (2002) Guidance for industry: drugs, biologics, and medical devices derived from bioengineered plants for use in humans and animals. Draft Guidance.
  • Fedosov, S.N., Laursen, N.B., Nexø, E., Moestrup, S.K., Petersen, T.E., Jensen, E.Ø. and Berglund, L. (2003) Human intrinsic factor expressed in the plant Arabidopsis thaliana. Eur. J. Biochem. 270, 33623367.
  • Fiedler, U., Phillips, J., Artsaenko, O. and Conrad, U. (1997) Optimization of scFv antibody production in transgenic plants. Immunotechnology, 3, 16205.
  • Flinn, J.E. and Zavon, J.A. (2004) Green Plants as biofactories for drugs. Biopharm. Int’l. 8, 4249.
  • Frank, B.H., Prouty, W.E., Heiney, R.E. and Walden, M.R. (1995) Process for turning a human insulin precursor to human insulin. U.S. Patent 5. 457,066.
  • Goel, G., Makkar, H.P.S., Francis, G. and Becker, K. (2007) Phorbol esters: structure, biological activity, and toxicity in animals. Int. J. Toxicol. 26, 279288.
  • Golovina, E.A., Wolkers, W.F. and Hoekstra, F.A. (1997) Long-term stability of protein secondary structure in dry seeds. Comp. Biochem. Physiol. A Physiol. 117, 343348.
  • Hennegan, K., Yang, D.C., Nguyen, D., Wu, L.Y., Goding, J., Huang, J.M., Guo, F.L., Huang, N. and Watkins, S.C. (2005) Improvement of human lysozyme expression in transgenic rice grain by combining wheat Triticum aestivum puroindoline b and rice Oryza sativa Gt1 promoters and signal peptides. Transgenic Res. 14, 583592.
  • Hintz, R.L. (1996) Current and potential therapeutic uses of Growth Hormone and Insulin—like growth factor. Endocrinol. Metab. Clin. North Am. 25, 759773.
  • Hood, E.E., Bailey, M.R., Beifuss, K., Magallanes-Lundback, M., Horn, M.E., Callaway, E., Drees, C., Delaney, D.E., Clough, R. and Howard, J.A. (2003) Criteria for high-level expression of a fungal laccase gene in transgenic maize. Plant Biotechnol. J. 1, 129140.
  • Huang, N. (2004) High-level protein expression system uses self-pollinating crops as hosts. BioProcess International, 2, 5459.
  • Jasicka-Misiaka, I., Lipoka, J., Nowakowskaa, E.M., Wieczoreka, P.P., Młynarzb, P. and Kafarskia, P. (2004) Antifungal activity of the carrot seed oil and its major sesquiterpene compounds Z. Naturforsch. 59c, 791796.
  • Kjeldsen, T., Balschmidt, P., Diers, I., Hach, M., Kaarsholm, N.C. and Ludvigsen, S. (2001) Expression of insulin in yeast: the importance of molecular adaptation for secretion and conversion. Biotechnol. Genet. Eng. Rev. 18, 89121.
  • Kusnadi, A.R., Hood, E.E., Witcher, D.R., Howard, J.A. and Nikolov, Z.L. (1998) Production and purification of two recombinant proteins form transgenic corn. Biotechnol. Prog. 14, 149155.
  • Liénard, D., Sourrouille, C., Gomord, V. and Faye, L. (2007) Pharming and transgenic plants. Biotechnol. Annu. Rev. 13, 115147.
  • Markley, N.A., Nykiforuk, C.L., Boothe, J.G. and Moloney, M.M. (2006) Producing proteins using transgenic oilbody-oleosin technology. BioPharm Int’.l 19, 3457.
  • McCormick, A.A., Reddy, S., Reinl, S.J., Cameron, T.I., Czerwinkski, D.K., Vojdani, F., Hanley, K.M., Garger, S.J., White, E.L., Novak, J., Barrett, J., Holtz, R.B., Tusé, D. and Levy, R. (2008) Plant-produced idiotype vaccines for the treatment of non-Hodgkin’s lymphoma: safety and immunogenicity in a phase I clinical study. Proc. Natl Acad. Sci. USA, 105, 1013110136.
  • Menkhaus, T.J., Bai, Y., Zhang, C., Nikolov, Z.L. and Glatz, C.E. (2004) Considerations for the recovery of recombinant proteins from plants. Biotechnol. Prog. 20, 10011014.
  • Mison, D. and Curling, J. (2000) The industrial production costs of recombinant therapeutic proteins expressed in transgenic corn. BioPharm. Int’l. 13, 4854.
  • Moody, A.D., Stan, M.A., Stan, M. and Gliemann, J. (1974) A simple free fat cell bioassay for insulin. Horm. Metab. Res. 6, 1216.
  • Nandi, S., Yalda, D., Lu, S., Nikolov, Z., Misaki, R., Fujiyama, K. and Huang, N. (2005) Process development and economic evaluation of recombinant human lactoferrin expressed in rice grain. Transgenic Res. 14, 237249.
  • Nicholson, L., Gonzalez-Melendi, P., Van Dolleweerd, C., Tuck, H., Perrin, Y., Ma, J.K., Fischer, R., Christou, P. and Stoger, E. (2005) A recombinant multimeric immunoglobulin expressed in rice shows assembly-dependent subcellular localization in endosperm cells. Plant Biotechnol. J. 3, 115127.
  • Nochi, T., Takagi, H., Yuki, Y., Yang, L., Masumura, T., Mejima, M., Nakanishi, U., Matsumura, A., Uozumi, A., Hiroi, T., Morita, S., Tanaka, K., Takaiwa, F. and Kiyono, H. (2007) Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination. Proc. Natl Acad. Sci. USA, 104, 1098610991.
  • Nykiforuk, C.L., Boothe, J.G., Murray, E.W., Keon, R.G., Goren, H.J., Markley, N.A. and Moloney, M.M. (2006) Transgenic expression and recovery of biologically active recombinant human insulin from Arabidopsis thaliana seeds. Plant Biotechnol. J. 4, 7785.
  • Parmenter, D.L., Boothe, J.G., Van Rooijen, G.J., Yeung, E.C. and Moloney, M.M. (1995) Production of biologically active hirudin in plant seeds using oleosin partitioning. Plant Mol. Biol. 6, 11671180.
  • Pen, J., Verwoerd, T.C. and Paridon, P.A. (1993) Phytase-containing transgenic seeds as a novel feed additive for improved phosphorus utilization. Biotechnology (N.Y.), 11, 811814.
  • Perrin, Y., Vaquero, C., Gerrard, I., Sack, M., Drossard, J., Stöger, E., Christou, P. and Fischer, R. (2000) Transgenic pea seeds as bioreactors for the production of a single-chain Fv fragment (scFV) antibody used in cancer diagnosis and therapy. Mol. Breeding, 6, 345352.
  • Petrucelli, S. et al. (2006) A KDEL-tagged monoclonal antibody is efficiently retained in the endoplasmic reticulum in leaves, but is both partially secreted and sorted to protein storage vacuoles in seeds. Plant Biotechnol. J. 4, 511527.
  • Philip, R., Darnowski, D.W., Maughan, P.J. and Vodkin, L.O. (2001) Processing and localization of bovine beta-casein expressed in transgenic soybean seeds under control of a soybean lectin expression cassette. Plant Sci. 61, 323335.
  • Ramírez, N., Oramas, P., Ayala, M., Rodríguez, M., Pérez, M. and Gavilondo, J. (2001) Expression and long-term stability of a recombinant single-chain Fv antibody fragment in transgenic Nicotiana tabacum seeds. Biotechnol. Lett. 23, 4749.
  • Robinson, D.G., Oliviusson, P. and Hinz, G. (2005) Protein sorting to the storage vacuoles of plants: a critical appraisal. Traffic, 6, 615625.
  • Van Rooijen, G.J. and Moloney, M.M. (1995) Plant seed oil-bodies as carriers for foreign proteins. Biotechnology (N.Y.), 13, 7277.
  • Sallon, S., Solowey, E., Cohen, Y., Korchinsky, R., Egli, M., Woodhatch, I., Simchoni, O. and Kislev, M. (2008) Germination, genetics, and growth of an ancient date seed. Science, 320, 14641469.
  • Scheller, J., Leps, M. and Conrad, U. (2006) Forcing single-chain variable fragment production in tobacco seeds by fusion to elastin-like polypeptides. Plant Biotechnol. J. 4, 243.
  • Schünmann, P.H.D., Coia, G. and Waterhouse, P.M. (2002) Biopharming the simpliRED™ HIV diagnostic reagent in barley, potato and tobacco. Mol. Breeding, 9, 113121.
  • Sengupta-Gopalan, C., Reichert, N.A., Barker, R.F., Hall, T.C. and Kemp, J.D. (1985) Developmentally regulated expression of the ß-phaseolin gene in tobacco seed. Proc. Natl. Acad. Sci. USA, 82, 33203324.
  • Seon, J.H., Szarka, S.J. and Moloney, M.M. (2002) A unique strategy for recovering recombinant proteins from molecular farming in affinity capture on engineered oilbodies. J. Plant Biotechnol. 4, 95101.
  • Shaaltiel, Y., Bartfeld, D., Hashmueli, S., Baum, G., Brill-Almon, E., Galili, G., Dym, O., Boldin Adamsky, S.A., Silman, I., Sussman, J.L., Futerman, A.H. and Aviezer, D. (2007) Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher’s disease using a plant cell system. Plant Biotechnol. J. 5, 579590.
  • Shen-Miller, J., Schopf, J.W., Harbottle, G., Cao, R.-J., Ouyang, S., Zhou, K.-S., Southon, J.R. and Liu, G.-H. (2002) Long-living lotus: germination and soil γ-irradiation of centuries-old fruits, and cultivation, growth, and phenotypic abnormalities of offspring. Am. J. Bot. 89, 236247.
  • Stoger, E., Sack, M., Perrin, Y., Vaquero, C., Torres, E., Twyman, R.M., Christou, P. and Fischer, R. (2002) Practical considerations for pharmaceutical antibody production in different crop systems. Mol. Breeding, 9, 149158.
  • Stoger, E., Sack, M., Nicholson, L., Fischer, R. and Christou, P. (2005) Recent progress in plantibody technology. Curr. Pharm. Des. 11, 24392457.
  • Stöger, E., Vaquero, C., Torres, E., Sack, M., Nicholson, L., Drossard, J., Williams, S., Keen, D., Perrin, Y., Christou, P. and Fischer, R. (2000) Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies. Plant Mol. Biol. 42, 583590.
  • Streatfield, S.J., Lane, J.R., Brooks, C.A., Barker, D.K., Poage, M.L., Mayor, J.M., Lamphear, B.J., Drees, C.F., Jilka, J.M., Hood, E.E. and Howard, J.A. (2003) Corn as a production system for human and animal vaccines. Vaccine, 21, 812815.
  • Szarka, S., Van Rooijen, G. and Moloney, M. (2006) Methods for the production of multimeric immunoglobulins, and related compositions. United States Patent 7. 098,383.
  • Torrent, M., Alvarez, I., Geli, M.I., Dalcol, I. and Ludevid, D. (1997) Lysine-rich modified gamma-zeins accumulate in protein bodies of transiently transformed maize endosperms. Plant Mol. Biol. 34, 139149.
  • Torrent, M., Llompart, B., Lasserre-Ramassamy, S., Llop-Tous, I., Bastida, M., Marzabal, P., Westerholm-Parvinen, A., Saloheimo, M., Heifetz, P.B. and Ludevid, M.D. (2009a) Eukaryotic protein production in designed storage organelles. BMC Biol. 7, 5.
  • Torrent, M., Llop-Tous, I. and Ludevid, M.D. (2009b) Protein body induction: a new tool to produce and recover recombinant proteins in plants. Methods Mol. Biol. 483, 193208.
  • Torres, E., Vaquero, C., Nicholson, L., Sack, M., Stöger, E., Drossard, J., Christou, P., Fischer, R. and Perrin, Y. (1999) Rice cell culture as an alternative production system for functional diagnostic and therapeutic antibodies. Transgenic Res. 8, 441449.
  • Twyman, R.M., Schillberg, S. and Fischer, R. (2005) Transgenic plants in the biopharmaceutical market. Expert Opin. Emerg. Drugs, 10, 185218.
  • Van Droogenbroeck, B., Cao, J., Stadlmann, J., Altmann, F., Colanesi, S., Hillmer, S., Robinson, D.G., Van Lerberge, E., Terryn, N., Van Montagu, M., Liang, M., Depicker, A. and De Jaeger, G. (2007) Aberrant localization and underglycosylation of highly accumulating single-chain Fv-Fc antibodies in transgenic Arabidopsis seeds. Proc. Natl. Acad. Sci. USA, 104, 14301435.
  • Vitale, A. and Pedrazzini, E. (2005) Recombinant pharmaceuticals from plants: the plant endomembrane system as bioreactor. Mol. Interv. 5, 216225.
  • Xiao, P., Kubo, H., Komiya, H., Higashiyama, K., Yan, Y., Li, J. and Ohmiya, S. (1999) Lupin alkaloids from seeds of Sophora viciifolia. Phytochemistry, 50, 189193.
  • Yang, D., Guo, F., Liu, B., Huang, N. and Watkins, S.C. (2003) Expression and localization of human lysozyme in the endosperm of transgenic rice. Planta, 216, 597603.
  • Zhong, Q., Gu, Z. and Glatz, C.E. (2006) Extraction of recombinant dog gastric lipase from transgenic corn seed. J. Agric. Food. Chem. 54, 80868092.