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Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression
Article first published online: 29 MAR 2011
DOI: 10.1111/j.1467-7652.2011.00613.x
© 2011 The Authors. Plant Biotechnology Journal © 2011 Society for Experimental Biology, Association of Applied Biologists and Blackwell Publishing Ltd
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How to Cite
Suzuki, K., Kaminuma, O., Yang, L., Takai, T., Mori, A., Umezu-Goto, M., Ohtomo, T., Ohmachi, Y., Noda, Y., Hirose, S., Okumura, K., Ogawa, H., Takada, K., Hirasawa, M., Hiroi, T. and Takaiwa, F. (2011), Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression. Plant Biotechnology Journal, 9: 982–990. doi: 10.1111/j.1467-7652.2011.00613.x
Publication History
- Issue published online: 9 NOV 2011
- Article first published online: 29 MAR 2011
- Received 24 November 2010; revised 10 February 2011; accepted 11 February 2011.
- Abstract
- Article
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- Supporting Information
- Cited By
Figure S1 Analysis of Der P1 (45–145) glycoprotein derived from rice seed.
Figure S2 Southern blot analysis of Der p 1 (45–145) was performed in EcoRI (E)- and HindIII (H)-digested genomic DNA of the non-transgenic control and transgenic rice seeds.
Figure S3 The localization of 13 kD prolamin in the Tg rice seeds was determined by immunohistochemical electron microscopy.
Figure S4 Potential of antigen-specific immune suppression by fed with purified rDer P1 dissolved in PBS.
Figure S5 The production of suppressive cytokine TGF-β and IL-10.
Figure S6 The frequency of CD4+CD25+Foxp3+ regulatory T cells.
| Filename | Format | Size | Description |
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| PBI_613_sm_f1-6.pdf | 238K | Supporting info item |
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