SEARCH

SEARCH BY CITATION

References

  • Apweiler, R., Hermjakob, H. and Sharon, N. (1999) On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database. Biochim. Biophys. Acta, 1473, 48.
  • Arlen, P.A., Singleton, M., Adamovicz, J.J., Ding, Y., Davoodi-Semiromi, A. and Daniell, H. (2008) Effective plague vaccination via oral delivery of plant cells expressing F1-V antigens in chloroplasts. Infect. Immun. 76, 36403650.
  • Aziz, M.A., Sikriwal, D., Singh, S., Jarugula, S., Kumar, P.A. and Bhatnagar, R. (2005) Transformation of an edible crop with the pagA gene of Bacillus anthracis. FASEB J. 19, 15011503.
  • Barone, P., Zhang, X.H. and Widholm, J.M. (2009) Tobacco plastid transformation using the feedback-insensitive anthranilate synthase [α]-subunit of tobacco (ASA2) as a new selectable marker. J. Exp. Bot. 60, 31953202.
  • Birch-Machin, I., Newell, C.A., Hibberd, J.M. and Gray, J.C. (2004) Accumulation of rotavirus VP6 protein in chloroplasts of transplastomic tobacco is limited by protein stability. Plant Biotechnol. J. 2, 261270.
  • Bock, R. and Warzecha, H. (2010) Solar-powered factories for new vaccines and antibiotics. Trends Biotechnol. 28, 246252.
  • Buhot, L., Horvàth, E., Medgyesy, P. and Lerbs-Mache, S. (2006) Hybrid transcription system for controlled plastid transgene expression. Plant J. 46, 700707.
  • Caddick, M.X., Greenland, A.J., Jepson, I., Krause, K.-P., Qu, N., Riddell, K.V., Salter, M.G., Schuch, W., Sonnewald, U. and Tomsett, A.B. (1998) An ethanol inducible gene switch for plants used to manipulate carbon metabolism. Nat. Biotechnol. 16, 177180.
  • Cardi, T., Lenzi, P. and Maliga, P. (2010) Chloroplasts as expression platforms for plant-produced vaccines. Expert Rev. Vaccines, 9, 893911.
  • Chase, C.D. (2007) Cytoplasmic male sterility: a window to the world of plant mitochondrial-nuclear interactions. Trends Genet. 23, 8190.
  • Chebolu, S. and Daniell, H. (2007) Stable expression of Gal/GalNAc lectin of Entamoeba histolytica in transgenic chloroplasts and immunogenicity in mice towards vaccine development for amoebiasis. Plant Biotechnol. J. 5, 230239.
  • Chebolu, S. and Daniell, H. (2009) Chloroplast-derived vaccine antigens and biopharmaceuticals: expression, folding, assembly and functionality. Curr. Top. Microbiol. Immunol. 332, 3354.
  • Corneille, S., Lutz, K., Svab, Z. and Maliga, P. (2001) Efficient elimination of selectable marker genes from the plastid genome by the CRE-lox site-specific recombination system. Plant J. 72, 171178.
  • Daniell, H. (2007) Transgene containment by maternal inheritance: effective or elusive? Proc. Natl Acad. Sci. USA, 104, 68796880.
  • Daniell, H., Datta, R., Varma, S., Gray, S. and Lee, S.B. (1998) Containment of herbicide resistance through genetic engineering of the chloroplast genome. Nat. Biotechnol. 16, 345348.
  • Daniell, H., Lee, S.B., Panchal, T. and Wiebe, P.O. (2001) Expression of the native cholera toxin B subunit gene and assembly as functional oligomers in transgenic tobacco chloroplasts. J. Mol. Biol. 311, 10011009.
  • Daniell, H., Singh, N.D., Mason, H. and Streatfield, S.J. (2009) Plant-made vaccine antigens and Biopharmaceuticals. Trends Plant Sci. 14, 669679.
  • Davoodi-Semiromi, A., Samson, N.P. and Daniell, H. (2009) The Green vaccine: a global strategy to combat infectious and autoimmune diseases. Hum. Vaccin. 5, 488493.
  • Davoodi-Semiromi, A., Schreiber, M., Nallapali, S., Verma, D., Singh, N.D., Banks, R.K., Chakrabarti, D. and Daniell, H. (2010) Chloroplast-derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery. Plant Biotechnol. J. 8, 223242.
  • De Cosa, B., Moar, W., Lee, S. B., Miller, M. and Daniell, H. (2001) Overexpression of the Bt cry2Aa2 operon in chloroplasts leads to formation of insecticidal crystals. Nat. Biotechnol. 19, 7174.
  • Dreesen, I.A., Hamri, G.C. and Fussenegger, M. (2010) Heat-stable oral alga-based vaccine protects mice from Staphylococcus aureus infection. J. Biotechnol. 145, 273280.
  • Farran, I., McCarthy-Suárez, I., Río-Manterola, F., Mansilla, C., Lasarte, J.J. and Mingo-Castel, Á.M. (2010) The vaccine adjuvant extra domain A from fibronectin retains its proinflammatory properties when expressed in tobacco chloroplasts. Planta, 231, 977990.
  • Faye, L., Boulaflous, A., Benchabane, M., Gomord, V. and Michaud, D. (2005) Protein modifications in the plant secretory pathway: current status and practical implications in molecular pharming. Vaccine, 23, 17701778.
  • Fernandez-San Millan, A., Ortigosa, S.M., Hervas-Stubbs, S., Corral-Martınez, P., Seguı-Simarro, J.M., Gaetan, J., Coursaget, P. and Veramendi, J. (2008) Human papillomavirus L1 protein expressed in tobacco chloroplasts self-assembles into virus-like particles that are highly immunogenic. Plant Biotechnol. J. 6, 427441.
  • Fischer, R., Stoger, E., Schillberg, S., Christou, P. and Twyman, R.M. (2004) Plant-based production of biopharmaceuticals. Curr. Opin. Plant Biol. 7, 152158.
  • Giorgi, C., Franconi, R. and Rybicki, E.P. (2010) Human papillomavirus vaccines in plants. Expert Rev. Vaccines, 9, 913924.
  • Glenz, K., Bouchon, B., Stehle, T., Wallich, R., Simon, M.M. and Warzecha, H. (2006) Production of a recombinant bacterial lipoprotein in higher plant chloroplasts. Nat. Biotechnol. 24, 7677.
  • Goffard, A. and Dubuisson, J. (2003) Glycosylation of hepatitis C virus envelope proteins. Biochimie, 85, 295301.
  • Goffard, A., Callens, N., Bartosch, B., Wychowski, C., François-Loïc Cosset, F.L., Montpellier, C. and Dubuisson, J. (2005) Role of N-linked glycans in the functions of hepatitis C virus envelope glycoproteins. J. Virol. 79, 84008409.
  • Granell, A., Fernández-del-Carmen, A. and Orzáez, D. (2010) In planta production of plant-derived and non-plant-derived adjuvants. Expert Rev. Vaccines, 9, 843858.
  • Guy, B. (2007) The perfect mix: recent progress in adjuvant research. Nat. Rev. Microbiol. 5, 505517.
  • Hagemann, R. (2004) The sexual inheritance of plant organelles. In Molecular Biology and Biotechnology of Plant Organelles: Chloroplasts and Mitochondria, (Daniell, H. and Chase, C., eds), pp. 93113. Netherlands: Springer.
  • Hasunuma, T., Miyazawa, S., Yoshimura, S., Shinzaki, Y., Tomizawa, K., Shindo, K., Choi, S.K., Misawa, N. and Miyake, C. (2008) Biosynthesis of astaxanthin in tobacco leaves by transplastomic engineering. Plant J. 55, 857868.
  • Herz, S., Fussl, M., Steiger, S. and Koop, H.U. (2005) Development of novel types of plastid transformation vectors and evaluation of factors controlling expression. Transgenic Res. 14, 969982.
  • Holmgren, J., Czerkinsky, C., Eriksson, K. and Mharandi, A. (2003) Mucosal immunisation and adjuvants: a brief overview of recent advances and challenges. Vaccine, 21(S2), S89S95.
  • Houdebine, L.M. (2009) Production of pharmaceutical proteins by transgenic animals. Comp. Immunol. Microbiol. Infect. Dis. 32, 107121.
  • Hu, A., Cattaneo, R., Schwartz, S. and Norrby, E. (1994) Role of N-linked oligosaccharide chains in the processing and antigenicity of measles virus hemagglutinin protein. J. Gen. Virol. 75, 10431052.
  • Iamtham, S. and Day, A. (2000) Removal of antibiotic resistance genes from transgenic tobacco plastids. Nat. Biotechnol. 18, 11721176.
  • Kang, T.J., Loc, N.H., Jang, M.O., Jang, Y.S., Kim, Y.S., Seo, J.E. and Yang, M.S. (2003) Expression of the B subunit of E. coli heat-labile enterotoxin in the chloroplasts of plants and its characterization. Transgenic Res. 12, 683691.
  • Kang, T.J., Han, S.C., Jang, M.O., Kang, K.H., Jang, Y.S. and Yang, M.S. (2004) Enhanced expression of B-subunit of Escherichia coli heat-labile enterotoxin in tobacco by optimization of coding sequence. Appl. Biochem. Biotechnol. 117, 175187.
  • Kieny, M.P., Lather, R.F., Drillien, R., Spehner, D., Skory, S., Schmitt, D., Wiktor, T., Koprowski, H. and Lecocq, J.P. (1984) Expression of rabies virus glycoprotein from a recombinant vaccinia virus. Nature, 312, 163166.
  • Kittiwongwattana, C., Lutz, K.A., Clark, M. and Maliga, P. (2007) Plastid marker gene excision by the phiC31 phage site-specific recombinase. Plant Mol. Biol. 64, 137143.
  • Klaus, S.M.J., Huang, F.-C., Golds, T.J. and Koop, H.-U. (2004) Generation of marker-free plastid transformants using a transiently cointegrated selection gene. Nat. Biotechnol. 22, 225229.
  • Koop, H.U., Herz, S., Golds, T.J. and Nickelsen, J. (2007) The genetic transformation of plastids. Top. Curr. Genet. 19, 457510.
  • Koya, V., Moayeri, M., Leppla, S.H. and Daniell, H. (2005) Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge. Infect. Immun. 73, 82668274.
  • Lee, M., Zhou, Y., Lung, R., Chye, M.L., Yip, W.K., Zee, S.Y. and Lam, E. (2006) Expression of viral capsid protein antigen against Epstein–Barr Virus in plastids of Nicotiana tabacum cv. SR1. Biotechnol. Bioeng. 20, 11291137.
  • Lenzi, P., Scotti, N., Alagna, F., Tornesello, M.L., Pompa, A., Vitale, A., De Stradis, A., Monti, L., Grillo, S., Buonaguro, F.M., Maliga, P. and Cardi, T. (2008) Translational fusion of chloroplast-expressed human papillomavirus type 16 L1 capsid protein enhances antigen accumulation in transplastomic tobacco. Transgenic Res. 17, 10911102.
  • Lin, H.C., Chen, S.F., Chang, S.F. and Liu, D.P. (2008) Mixed vaccines against diphtheria, pertussis, and tetanus. Taiwan Epidemiol. Bull. 24, 347356.
  • Liu, C.W., Lin, C.C., Yiu, J.C., Chen, J.J.W. and Tseng, M.J. (2008) Expression of a Bacillus thuringiensis toxin (cry1Ab) gene in cabbage (Brassica oleracea L. var. capitata L.) chloroplasts confers high insecticidal efficacy against Plutella xylostella. Theor. Appl. Genet. 117, 7588.
  • Lössl, A., Eibl, C., Harloff, H.J., Jung, C. and Koop, H.U. (2003) Polyester synthesis in transplastomic tobacco (Nicotiana tabacum L.): significant contents of polyhydroxybutyrate are associated with growth reduction. Plant Cell Rep. 21, 891899.
  • Lössl, A., Bohmert, K., Harloff, H., Eibl, C., Mühlbauer, S. and Koop, H.U. (2005) Inducible trans-activation of plastid transgenes: expression of the R. eutropha phb operon in transplastomic tobacco. Plant Cell Physiol. 46, 14621471.
  • Lutz, K.A. and Maliga, P. (2007) Construction of marker-free transplastomic plants. Curr. Opin. Biotechnol. 18, 107114.
  • Ma, J.K., Drake, P.M. and Christou, P. (2003) The production of recombinant pharmaceutical proteins in plants. Nat. Rev. Genet. 4, 794805.
  • Madesis, P., Osathanunkul, M., Georgopoulou, U., Gisby, M.F., Mudd, E.A., Nianiou, I., Tsitoura, P., Mavromara, P., Tsaftaris, A. and Daya, A. (2010) A hepatitis C virus core polypeptide expressed in chloroplasts detects anti-core antibodies in infected human sera. J. Biotechnol. 145, 377386.
  • Magee, A.M., Coyne, S., Murphy, D., Horvath, E.M., Medgyesy, P. and Kavanagh, T.A. (2004) T7 RNA polymerase-directed expression of an antibody fragment transgene in plastids causes a semi-lethal pale-green seedling phenotype. Transgenic Res. 13, 325337.
  • Maliga, P. (2002) Engineering the plastid genome of higher plants. Curr. Opin. Plant Biol. 5, 164172.
  • McCabe, M.S., Klaas, M., Gonzalez-Rabade, N., Poage, M., Badillo-Corona, J.A., Zhou, F., Karcher, D., Bock, R., Gray, J.C. and Dix, P.J. (2008) Plastid transformation of high-biomass tobacco variety Maryland Mammoth for production of human immunodeficiency virus type 1 (HIV-1) p24 antigen. Plant Biotechol. J. 6, 914929.
  • Meyers, A., Chakauya, E., Shephard, E., Tanzer, F.L., Maclean, J., Lynch, A., Williamson, A.L. and Rybicki, E.P. (2008) Expression of HIV-1 antigens in plants as potential subunit vaccines. BMC. Biotechnol. 8, 53.
  • Molina, A., Hervas-Stubbs, S., Daniell, H., Mingo-Castel, A.M. and Veramendi, J. (2004) High-yield expression of a viral peptide animal vaccine in transgenic tobacco chloroplasts. Plant Biotechnol. J. 2, 141153.
  • Moreillon, P. and Que, Y.A. (2004) Infective endocarditis. Lancet, 363, 139149.
  • Morgenfeld, M., Segretin, M.E., Wirth, S., Lentz, E., Zelada, A., Mentaberry, A., Gissmann, L. and Bravo-Almonacid, F. (2009) Potato virus X coat protein fusion to Human Papillomavirus 16 E7 oncoprotein enhance antigen stability and accumulation in tobacco chloroplast. Mol. Biotechnol. 43, 243249.
  • Mühlbauer, S.K. and Koop, H.U. (2005) External control of transgene expression in tobacco plastid using the bacterial lac repressor. Plant J. 43, 941946.
  • Nashar, T.O., Amin, T., Marcello, A. and Hirst, T.R. (1993) Current progress in the development of the B subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as carriers for the oral delivery of heterologous antigens and epitopes. Vaccine, 11, 235240.
  • Oey, M., Lohse, M., Kreikemeyer, B. and Bock, R. (2009) Exhaustion of the chloroplast protein synthesis capacity by massive expression of a highly stable protein antibiotic. Plant J. 57, 436445.
  • Pelletier, G. and Budar, F. (2007) The molecular biology of cytoplasmically inherited male sterility and prospects for its engineering. Curr. Opin. Biotechnol. 18, 121125.
  • Prehaud, C., Takehara, K., Flamand, A. and Bishop, D.H.L. (1989) Immunogenic and protective properties of rabies virus glycoprotein expressed by baculovirus vectors. Virology, 173, 390399.
  • Rice, J., Ainley, W.M. and Shewen, P. (2005) Plant-made vaccines: biotechnology and immunology in animal health. Anim. Health Res. Rev. 6, 199209.
  • Rigano, M.M., Manna, C., Giulini, A., Vitale, A. and Cardi, T. (2009a) Plants as biofactories for the production of subunit vaccines against bio-security-related bacteria and viruses. Vaccine, 27, 34633466.
  • Rigano, M.M., Manna, C., Giulini, A., Pedrazzini, E., Capobianchi, M., Castilletti, C., Di, C.A., Ippolito, G., Beggio, P., De Giuli, M.C., Monti, L., Vitale, A. and Cardi, T. (2009b) Transgenic chloroplasts are efficient sites for high-yield production of the vaccinia virus envelope protein A27L in plant cells. Plant Biotechnol. J. 7, 577591.
  • Rosales-Mendoza, S., Alpuche-Solís, Á.G., Soria-Guerra, R.E., Moreno-Fierros, L., Martínez-González, L., Herrera-Díaz, A. and Korban, S.S. (2009) Expression of an Escherichia coli antigenic fusion protein comprising the heat labile toxin B subunit and the heat stable toxin, and its assembly as a functional oligomer in transplastomic tobacco plants. Plant J. 57, 4554.
  • Ruf, S., Hermann, M., Berger, I.J., Carrer, H. and Bock, R. (2001) Stable genetic transformation of tomato plastids and expression of a foreign protein in fruit. Nat. Biotechnol. 19, 870875.
  • Ruf, S., Karcher, D. and Bock, R. (2007) Determining the transgene containmentlevel provided by chloroplast transformation. Proc. Natl Acad. Sci. USA, 104, 69987002.
  • Ruhlman, T., Ahangari, R., Devine, A., Samsam, M. and Daniell, H. (2007) Expression of cholera toxin B-proinsulin fusion protein in lettuce and tobacco chloroplasts–oral administration protects against development of insulitis in non-obese diabetic mice. Plant Biotechnol. J. 5, 495510.
  • Ruhlman, T., Verma, D., Samson, N. and Daniell, H. (2010) The role of heterologous chloroplast sequence elements in transgene integration and expression. Plant Physiol. 152, 20882104.
  • Ruiz, O.N. and Daniell, H. (2005) Engineering cytoplasmic male sterility via the chloroplast genome by expression of ß-ketothiolase. Plant Physiol. 138, 12321246.
  • Rybicki, E.P. (2009) Plant-produced vaccines: promise and reality. Drug Discov. Today, 14, 1624.
  • Rybicky, E.P. (2010) Plant-made vaccines for humans and animals. Plant Biotechnol. J. 8, 620637.
  • Salyaev, R.K., Rigano, M.M. and Rekoslavskaya, N.I. (2010) Development of plant-based mucosal vaccines against widespread infectious diseases. Expert Rev. Vaccines, 9, 937946.
  • Sánchez, J.S. and Holmgren, J. (2008) Cholera toxin structure, gene regulation and pathophysiological and immunological aspects. Cell. Mol. Life Sci. 65, 13471360.
  • Schädlich, L., Senger, T., Gerlach, B., Mücke, N., Klein, C., Bravo, I.G., Müller, M. and Gissmann, L. (2009) Analysis of modified human papillomavirus type 16 L1 capsomeres: the ability to assemble into larger particles correlates with higher immunogenicity. J. Virol. 83, 76907705.
  • Scotti, N., Alagna, F., Ferraiolo, E., Formisano, G., Sannino, L., Buonaguro, L., De Stradis, A., Vitale, A., Monti, L., Grillo, S., Buonaguro, F.M. and Cardi, T. (2009) High-level expression of the HIV-1 Pr55gag polyprotein in transgenic tobacco chloroplasts. Planta, 229, 11091122.
  • Sim, J.S., Pak, H.K., Kim, D.S., Lee, S.B., Kim, Y.H. and Hahn, B.S. (2009) Expression and characterization of synthetic heat-labile enterotoxin b subunit and hemagglutininneuraminidase-neutralizing epitope fusion protein in Escherichia coli and tobacco chloroplasts. Plant Mol. Biol. Rep. 27, 388399.
  • Singh, A.K., Verma, S.S. and Bansal, K.C. (2010) Plastid transformation in eggplant (Solanum melongena L.). Transgenic Res. 19, 113119.
  • Smith, J.S., Lindsay, L., Hoots, B., Keys, J., Franceschi, S., Winer, R. and Clifford, G.M. (2007) Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update. Int. J. Cancer, 121, 621632.
  • Soria-Guerra, R.E., Alpuche-Solís, Á.G., Rosales-Mendoza, S., Moreno-Fierros, L., Bendik, E.M., Martínez-González, L. and Korban, S.S. (2009) Expression of a multi-epitope DPT fusion protein in transplastomic tobacco plants retains both antigenicity and immunogenicity of all three components of the functional oligomer. Planta, 229, 12931302.
  • Streatfield, S.J. and Howard, J.A. (2003a) Plant-based vaccines. Int. J. Parasitol. 33, 479493.
  • Streatfield, S.J. and Howard, J.A. (2003b) Plant production systems for vaccines. Expert Rev. Vaccines, 2, 763775.
  • Svab, Z. and Maliga, P. (2007) Exceptional transmission of plastids and mitochondria from the transplastomic pollen parent and its impact on transgene containment. Proc. Natl Acad. Sci. USA, 104, 70037008.
  • Tissot, G., Canard, H., Nadai, M., Martone, A., Botterman, J. and Dubald, M. (2008) Translocation of aprotinin, a therapeutic protease inhibitor, into the thylakoid lumen of genetically engineered tobacco chloroplasts. Plant Biotechnol. J. 6, 309320.
  • Tiwari, S., Verma, P.C., Singh, P.K. and Tuli, R. (2009) Plants as bioreactors for the production of vaccine antigens. Biotechnol. Adv. 27, 449467.
  • Tregoning, J.S., Nixon, P., Kuroda, H., Svab, Z., Clare, S., Bowe, F., Fairweather, N., Jimmy Ytterberg, J., van Wijk, K.J., Dougan, G. and Maliga, P. (2003) Expression of tetanus toxin Fragment C in tobacco chloroplasts. Nucleic Acids Res. 31, 11741179.
  • Tregoning, J., Maliga, P., Dougan, G. and Nixon, P.J. (2004) New advances in the production of edible plant vaccines: chloroplast expression of a tetanus vaccine antigen, TetC. Phytochemistry, 65, 989994.
  • Tregoning, J.S., Clare, S., Bowe, F., Edwards, L., Fairweather, N., Qazi, O., Nixon, P.J., Maliga, P., Dougan, G. and Hussell, T. (2005) Protection against tetanus toxin using a plant-based vaccine. Eur. J. Immunol. 35, 13201326.
  • Tungsuchat, T., Kuroda, H., Narangajavana, J. and Maliga, P. (2006) Gene activation in plastids by the CRE site-specific recombinase. Plant Mol. Biol. 61, 711718.
  • Verhounig, A., Karcher, D. and Bock, R. (2010) Inducible gene expression from the plastid genome by a synthetic riboswitch, Proc. Proc. Natl Acad. Sci. USA, 107, 62046209.
  • Waheed, M.T., Thönes, N., Müller, M., Hassan, S.W., Razavi, N.M., Lössl, E., Kaul, H.P. and Lössl, A.G. (2011) Transplastomic expression of a modified human papillomavirus L1 protein leading to the assembly of capsomeres in tobacco: a step towards cost-effective second-generation vaccines. Transgenic Res., 20, 271282.
  • Walsh, G. and Jefferis, R. (2006) Post-translational modifications in the context of therapeutic proteins. Nat. Biotechnol. 24, 12411252.
  • Wang, X., Brandsma, M., Tremblay, R., Maxwell, D., Jevnikar, A.M., Huner, N. and Ma, S. (2008) A novel expression platform for the production of diabetes-associated autoantigen human glutamic acid decarboxylase (hGAD65). BMC Biotechnol. 8, 87. doi:10.1186/1472-6750-8-87.
  • Watson, J., Koya, V., Leppla, S.H. and Daniell, H. (2004) Expression of Bacillus anthracis protective antigen in transgenic chloroplasts of tobacco, a non-food/feed crop. Vaccine, 22, 43744384.
  • Wiktor, T.J., Macfarlan, R.I., Reagan, K.J., Dietzschold, B., Curtis, P.J., Wunner, W.H., Kieny, M.P., Lathe, R., Lecocq, J.P., Mackett, M., Moss, B. and Koprowski, H. (1984) Protection from rabies by a vaccinia virus recombinant containing the rabies virus glycoprotein gene. Proc. Natl Acad. Sci. USA, 81, 71947198.
  • Wiser, I., Balicer, R.D. and Cohen, D. (2007) An update on smallpox vaccine candidates and their role in bioterrorism related vaccination strategies. Vaccine, 25, 976984.
  • World Health Organization (1999) World Health Organization Report on Infectious Diseases. Removing Obstacles to Healthy Development. Chapter 15 and 16. Geneva: World Health Organization. Available from http://www.who.int/infectious-disease-report/index-rpt99.html
  • World Health Organization (2010) Immunization, Vaccines and Biologicals. SAGE meeting of 9–11 November 2010. Gender and immunization. Report for SAGE, November 2010. Swiss Tropical and Public Health Institute. Geneva: World Health Organization. Available from http://www.who.int/immunization/sage/1_immunization_gender_reports_without_graphics.pdf
  • World Health Organization (2008) Global Burden of Disease (GBD). The Global Burden of Diseases 2004 Update. Geneva: World Health Organization. Available from http://www.who.int/healthinfo/global_burden_disease/2004_report_update/en/index.html
  • Wunner, W.H., Dietzschold, B., Curtis, P.J. and Wiktor, T.J. (1983) Rabies subunit vaccines. J. Gen. Virol. 64, 16491656.
  • Xing, Y., Huang, Z., Lin, Y., Li, J., Chou, T.H., Lu, S. and Wang, S. (2008) The ability of Hepatitis B surface antigen DNA vaccine to elicit cell-mediated immune responses, but not antibody responses, was affected by the deglysosylation of S antigen. Vaccine, 26, 51455152.
  • Yelverton, E., Norton, S., Obijeski, J.F. and Goedel, D.V. (1983) Rabies virus glycoprotein analogs: biosynthesis in Escherichia coli. Science, 219, 614619.
  • Youm, J.W., Jeon, J.H., Kim, H., Min, S.R., Kim, M.S., Joung, H., Jeong, W.J. and Kim, H.S. (2010) High-level expression of a human β-site APP cleaving enzyme in transgenic tobacco chloroplasts and its immunogenicity in mice. Transgenic Res., 19, 10991108.
  • Yuan, H., Estes, P.A., Chen, Y., Newsome, J., Olcese, V.A., Garcea, R.L. and Schlegel, R. (2001) Immunization with a pentameric L1 fusion protein protects against papillomavirus infection. J. Virol. 75, 78487853.
  • Zhou, Y.X., Lee, M.Y., Ng, J.M., Chye, M.L., Yip, W.K., Zee, S.Y. and Lam, E. (2006) A truncated hepatitis E virus ORF2 protein expressed in tobacco plastids is immunogenic in mice. World J. Gastroenterol. 12, 306312.
  • Zhou, F., Badillo-Corona, J.A., Karcher, D., Gonzalez-Rabade, N., Piepenburg, K., Borchers, A.M., Maloney, A.P., Kavanagh, T.A., Gray, J.C. and Bock, R. (2008) High-level expression of human immunodeficiency virus antigens from the tobacco and tomato plastid genomes. Plant Biotechnol. J. 6, 897913.