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  • Abbadi, A., Domergue, F., Bauer, J., Napier, J.A., Welti, R., Zähringer, U., Cirpus, P. and Heinz, E. (2004) Biosynthesis of very-long-chain polyunsaturated fatty acids in transgenic oilseeds: constraints on their accumulation. Plant Cell, 16, 27342748.
  • Beaudoin, F., Michaelson, L.V., Hey, S.J., Lewis, M.J., Shewry, P.R., Sayanova, O. and Napier, J.A. (2000) Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway. Proc. Natl Acad. Sci. USA, 97, 64216426.
  • Cheng, B., Wu, G., Vrinten, P., Falk, K., Bauer, J. and Qiu, X. (2010) Towards the production of high levels of eicosapentaenoic acid in transgenic plants: the effects of different host species, genes and promoters. Transgenic Res. 19, 221229.
  • Cho, H.P., Nakamura, M.T. and Clarke, S.D. (1999) Cloning, expression, and nutritional regulation of the mammalian Δ6 desaturase. J. Biol. Chem. 274, 471477.
  • Damude, H.G. and Kinney, A.J. (2008) Enhancing plant seed oils for human nutrition. Plant Physiol. 147, 962968.
  • Domergue, F., Abbadi, A., Ott, C., Zank, T.K., Zähringer, U. and Heinz, E. (2003) Acyl carriers used as substrates by the desaturases and elongases involved in very long-chain polyunsaturated fatty acids biosynthesis reconstituted in yeast. J. Biol. Chem. 278, 3511535126.
  • Domergue, F., Abbadi, A. and Heinz, E. (2005a) Relief for fish stocks: oceanic fatty acids in transgenic oilseeds. Trends Plant Sci. 10, 112116.
  • Domergue, F., Abbadi, A., Zähringer, U., Moreau, H. and Heinz, E. (2005b) In vivo characterization of the first acyl-CoA Δ6-desaturase from a member of the plant kingdom, the microalga Ostreococcus tauri. Biochem. J. 389, 483490.
  • Drexler, H., Spiekermann, P., Meyer, A., Domergue, F., Zank, T., Sperling, P., Abbadi, A. and Heinz, E. (2003) Metabolic engineering of fatty acids for breeding of new oilseed crops: strategies, problems and first results. J. Plant Physiol. 160, 779802.
  • Eckert, H., LaVallee, B., Schweiger, B.J., Kinney, A.J., Cahoon, E.B. and Clemente, T. (2006) Co-expression of the borage Δ6 desaturase and the Arabidopsis Δ15 desaturase results in high accumulation of stearidonic acid in the seeds of transgenic soybean. Planta, 224, 10501057.
  • Gehringer, A., Friedt, W., Lühs, W. and Snowdon, R.J. (2006) Genetic mapping of agronomic traits in false flax (Camelina sativa subsp. sativa). Genome, 49, 15551563.
  • Griffiths, G., Stobart, A.K. and Stymne, S. (1988) Δ6- and Δ12-desaturase activities and phosphatidic acid formation in microsomal preparations from the developing cotyledons of common borage (Borago officinalis). Biochem. J. 252, 641647.
  • Hoffmann, M., Wagner, M., Abbadi, A., Fulda, M. and Feussner, I. (2008) Metabolic engineering of omega3-very long chain polyunsaturated fatty acid production by an exclusively acyl-CoA-dependent pathway. J. Biol. Chem. 283, 2235222362.
  • Hong, H., Datla, N., Reed, D.W., Covello, P.S., MacKenzie, S.L. and Qiu, X. (2002) High-level production of γ-linolenic acid in Brassica juncea using a Δ6 desaturase from Pythium irregulare. Plant Physiol. 129, 354362.
  • Jackson, F.M., Fraser, T.C., Smith, M.A., Lazarus, C., Stobart, A.K. and Griffiths, G. (1998) Biosynthesis of C18 polyunsaturated fatty acids in microsomal membrane preparations from the filamentous fungus Mucor circinelloides. Eur. J. Biochem. 252, 513519.
  • Larson, T.R. and Graham, I.A. (2001) A novel technique for the sensitive quantification of acyl CoA esters from plant tissues. Plant J. 25, 115125.
  • Lu, C. and Kang, J. (2008) Generation of transgenic plants of a potential oilseed crop Camelina sativa by Agrobacterium-mediated transformation. Plant Cell Rep. 27, 273278.
  • Lu, C., Napier, J.A., Clemente, T.E. and Cahoon, E.B. (2011) New frontiers in oilseed biotechnology: meeting the global demand for vegetable oils for food, feed, biofuel, and industrial applications. Curr. Opin. Biotechnol. 22, 252259.
  • Marquardt, A., Stöhr, H., White, K. and Weber, B.H. (2000) cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics, 66, 175183.
  • Napier, J.A. (2007) The production of unusual fatty acids in transgenic plants. Annu. Rev. Plant Biol. 58, 295319.
  • Napier, J.A. and Graham, I.A. (2010) Tailoring plant lipid composition: designer oilseeds come of age. Curr. Opin. Plant Biol. 13, 330337.
  • Napier, J.A. and Michaelson, L.V. (2001) Genomic and functional characterization of polyunsaturated fatty acid biosynthesis in Caenorhabditis elegans. Lipids, 36, 761766.
  • Napier, J.A., Michaelson, L.V. and Sayanova, O. (2003) The role of cytochrome b5 fusion desaturases in the synthesis of polyunsaturated fatty acids. Prostaglandins Leukot. Essent. Fatty Acids 68, 135143.
  • Napier, J.A., Sayanova, O., Qi, B. and Lazarus, C.M. (2004) Progress toward the production of long-chain polyunsaturated fatty acids in transgenic plants. Lipids, 39, 10671075.
  • Okayasu, T., Nagao, M., Ishibashi, T. and Imai, Y. (1981) Purification and partial characterization of linoleoyl-CoA desaturase from rat liver microsomes. Arch. Biochem. Biophys. 206, 2128.
  • Petrie, J.R., Shrestha, P., Mansour, M.P., Nichols, P.D., Liu, Q. and Singh, S.P. (2010) Metabolic engineering of omega-3 long-chain polyunsaturated fatty acids in plants using an acyl-CoA Δ6-desaturase with omega3-preference from the marine microalga Micromonas pusilla. Metab. Eng. 12, 233240.
  • Robert, S.S. (2006) Production of eicosapentaenoic and docosahexaenoic acid-containing oils in transgenic land plants for human and aquaculture nutrition. Mar. Biotechnol. (NY) 8, 103109.
  • Robert, S.S., Singh, S.P., Zhou, X.-R., Petrie, J.R., Blackburn, S.I., Mansour, P.M., Nichols, P.D., Liu, Q. and Green, A.G. (2005) Metabolic engineering of Arabidopsis to produce nutritionally important DHA in seed oil. Funct. Plant Biol. 32, 473479.
  • Sato, S., Xing, A., Ye, X., Schweiger, B., Kinney, A.J., Graef, G. and Clemente, T.E. (2004) Production of γ-linolenic acid and stearidonic acid in seeds of marker-free transgenic soybean. Crop Sci. 44, 646652.
  • Sayanova, O., Smith, M.A., Lapinskas, P., Stobart, A.K., Dobson, G., Christie, W.W., Shewry, P.R. and Napier, J.A. (1997) Expression of a borage desaturase cDNA containing an N-terminal cytochrome b5 domain results in the accumulation of high levels of Δ6-desaturatedfatty acids in transgenic tobacco. Proc. Natl Acad. Sci. USA, 94, 42114216.
  • Sayanova, O., Haslam, R., Venegas-Calerón, M. and Napier, J.A. (2006) Identification of Primula “front-end” desaturases with distinct n-6 or n-3 substrate preferences. Planta, 224, 12691277.
  • Sayanova, O., Haslam, R.P., Calerón, M.V., López, N.R., Worthy, C., Rooks, P., Allen, M.J. and Napier, J.A. (2011) Identification and functional characterisation of genes encoding the omega-3 polyunsaturated fatty acid biosynthetic pathway from the coccolithophore Emiliania huxleyi. Phytochemistry, 72, 594600.
  • Sperling, P., Linscheid, M., Stöcker, S., Mühlbach, H.P. and Heinz, E. (1993) In vivo desaturation of cis-Δ9-monounsaturated to cis-Δ9,12-diunsaturated alkenylether glycerolipids. J. Biol. Chem. 268, 2693526940.
  • Sprecher, H. and Chen, Q. (1999) Polyunsaturated fatty acid biosynthesis: a microsomal-peroxisomal process. Prostaglandins Leukot. Essent. Fatty Acids 60, 317321.
  • Stymne, S. and Stobart, A.K. (1986) Biosynthesis of γ-linolenic acid in cotyledons and microsomal preparations of the developing seeds of common borage (Borago officinalis). Biochem. J. 240, 385393.
  • Tonon, T., Sayanova, O., Michaelson, L.V., Qing, R., Harvey, D., Larson, T.R., Li, Y., Napier, J.A. and Graham, I.A. (2005) Fatty acid desaturases from the microalga Thalassiosira pseudonana. FEBS J. 272, 34013412.
  • Tripodi, K.E., Buttigliero, L.V., Altabe, S.G. and Uttaro, A.D. (2006) Functional characterization of front-end desaturases from trypanosomatids depicts the first polyunsaturated fatty acid biosynthetic pathway from a parasitic protozoan. FEBS J. 273, 271280.
  • Venegas-Calerón, M., Sayanova, O. and Napier, J.A. (2010) An alternative to fish oils: metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids. Prog. Lipid Res. 49, 108119.
  • Zank, T.K., Zähringer, U., Beckmann, C., Pohnert, G., Boland, W., Holtorf, H., Reski, R., Lerchl, J. and Heinz, E. (2002) Cloning and functional characterisation of an enzyme involved in the elongation of Δ6-polyunsaturated fatty acids from the moss Physcomitrella patens. Plant J. 31, 255268.
  • Zheng, X., Tocher, D.R., Dickson, C.A., Bell, J.G. and Teale, A.J. (2005) Highly unsaturated fatty acid synthesis in vertebrates: new insights with the cloning and characterization of a delta6 desaturase of Atlantic salmon. Lipids, 40, 1324.