Duchenne muscle activity evaluation and muscle function preservation: is it possible a prophylactic strategy?
Article first published online: 23 NOV 2007
© 2007 The Authors
Volume 9, Issue 2, pages 121–139, March 2008
How to Cite
Palmieri, B., Sblendorio, V., Ferrari, A. and Pietrobelli, A. (2008), Duchenne muscle activity evaluation and muscle function preservation: is it possible a prophylactic strategy?. Obesity Reviews, 9: 121–139. doi: 10.1111/j.1467-789X.2007.00423.x
- Issue published online: 23 NOV 2007
- Article first published online: 23 NOV 2007
- Received 24 April 2007; revised 6 October 2007; accepted 22 October 2007
- mdx mice;
- muscle injury;
- resting energy expenditure
Duchenne muscular dystrophy yields pervasive and progressive muscle mass loss. In the current measures relating to the monitoring of disease progression the following are relevant (i): the type of scale used, (ii) the clinical significance of the attribute being measured and (iii) the mathematical properties of the data provided. The high prevalence of obesity at an early stage of this pathology could result not only from reduced physical activity, but also from low resting energy expenditure, abnormal nutrient utilization or overfeeding. This muscle weakness may be attenuated by regular low-intensity exercise. However, there is a critical lack of data to support appropriate exercise prescription. Because inappropriate activity may exacerbate the dystrophic process, a systematic analysis of muscle function to determine potential exercise load thresholds to avoid injury in dystrophic mice and dogs, and then in humans is recommended.