Molecular network of obesity: what does it promise for pharmacotherapy?
Article first published online: 23 NOV 2007
Journal compilation © 2007 The International Association for the Study of Obesity. No claim to original US government works
Volume 9, Issue 3, pages 236–245, May 2008
How to Cite
Myslobodsky, M. (2008), Molecular network of obesity: what does it promise for pharmacotherapy?. Obesity Reviews, 9: 236–245. doi: 10.1111/j.1467-789X.2007.00424.x
- Issue published online: 23 NOV 2007
- Article first published online: 23 NOV 2007
- Received 21 August 2007; revised 30 October 2007; accepted 31 October 2007
There is growing evidence that receptors that respond to orexigenic and anorexigenic signals of respective neuropeptides are also implicated in cognitive, emotional, sensory and motor functions. How do these signals trigger a particular appetitive function while also acting in so different contexts in controlling non-appetitive behaviours? This perspective seeks an answer in their peculiar modular organization when each module planted in complex networks controlling appetite is also engaged in different domains. Network analysis may be essential in considering pharmacotherapeutic interventions and, in particular, when anticipating untoward central effects of agents explored from a therapeutic point of view.