Funding: This study received no funds from any source.
Prepregnancy BMI and the risk of gestational diabetes: a systematic review of the literature with meta-analysis
Article first published online: 1 DEC 2008
© 2008 The Authors. Journal compilation © 2008 International Association for the Study of Obesity
Volume 10, Issue 2, pages 194–203, March 2009
How to Cite
Torloni, M. R., Betrán, A. P., Horta, B. L., Nakamura, M. U., Atallah, A. N., Moron, A. F. and Valente, O. (2009), Prepregnancy BMI and the risk of gestational diabetes: a systematic review of the literature with meta-analysis. Obesity Reviews, 10: 194–203. doi: 10.1111/j.1467-789X.2008.00541.x
- Issue published online: 23 FEB 2009
- Article first published online: 1 DEC 2008
- Received 24 July 2008; revised 1 September 2008; accepted 3 October 2008
- Body mass index;
- gestational diabetes;
The objective of this study is to assess and quantify the risk for gestational diabetes mellitus (GDM) according to prepregnancy maternal body mass index (BMI). The design is a systematic review of observational studies published in the last 30 years. Four electronic databases were searched for publications (1977–2007). BMI was elected as the only measure of obesity, and all diagnostic criteria for GDM were accepted. Studies with selective screening for GDM were excluded. There were no language restrictions. The methodological quality of primary studies was assessed. Some 1745 citations were screened, and 70 studies (two unpublished) involving 671 945 women were included (59 cohorts and 11 case–controls). Most studies were of high or medium quality. Compared with women with a normal BMI, the unadjusted pooled odds ratio (OR) of an underweight woman developing GDM was 0.75 (95% confidence interval [CI] 0.69 to 0.82). The OR for overweight, moderately obese and morbidly obese women were 1.97 (95% CI 1.77 to 2.19), 3.01 (95% CI 2.34 to 3.87) and 5.55 (95% CI 4.27 to 7.21) respectively. For every 1 kg m−2 increase in BMI, the prevalence of GDM increased by 0.92% (95% CI 0.73 to 1.10). The risk of GDM is positively associated with prepregnancy BMI. This information is important when counselling women planning a pregnancy.