The paper and the data have not previously been published, either in whole or in part. No similar paper is in press or under review elsewhere. The submitted paper is an independent contribution.
Endocrine-disrupting chemicals and obesity development in humans: A review
Version of Record online: 4 APR 2011
© 2011 The Authors. obesity reviews © 2011 International Association for the Study of Obesity
Volume 12, Issue 8, pages 622–636, August 2011
How to Cite
Tang-Péronard, J. L., Andersen, H. R., Jensen, T. K. and Heitmann, B. L. (2011), Endocrine-disrupting chemicals and obesity development in humans: A review. Obesity Reviews, 12: 622–636. doi: 10.1111/j.1467-789X.2011.00871.x
• Each author has contributed to the conceptions and design of the work, the acquisition of data or the analysis of the data in a manner substantial enough to take public responsibility for it.
• Each has reviewed the final version of the manuscript and approves it for publication.
- Issue online: 21 JUL 2011
- Version of Record online: 4 APR 2011
- Received 17 November 2010; revised 31 January 2011; accepted 3 February 2011
- endocrine disruptors;
This study reviewed the literature on the relations between exposure to chemicals with endocrine-disrupting abilities and obesity in humans. The studies generally indicated that exposure to some of the endocrine-disrupting chemicals was associated with an increase in body size in humans. The results depended on the type of chemical, exposure level, timing of exposure and gender. Nearly all the studies investigating dichlorodiphenyldichloroethylene (DDE) found that exposure was associated with an increase in body size, whereas the results of the studies investigating polychlorinated biphenyl (PCB) exposure were depending on dose, timing and gender. Hexachlorobenzene, polybrominated biphenyls, beta-hexachlorocyclohexane, oxychlordane and phthalates were likewise generally associated with an increase in body size. Studies investigating polychlorinated dibenzodioxins and polychlorinated dibenzofurans found either associations with weight gain or an increase in waist circumference, or no association. The one study investigating relations with bisphenol A found no association. Studies investigating prenatal exposure indicated that exposure in utero may cause permanent physiological changes predisposing to later weight gain. The study findings suggest that some endocrine disruptors may play a role for the development of the obesity epidemic, in addition to the more commonly perceived putative contributors.