Financial support: This was supported by a National Health and Medical Research Council grant (No. 465130), a VicHealth fellowship to AP, and an Australian Post-graduate Award to EW and RFP.
Increasing body weight and risk of limitations in activities of daily living: a systematic review and meta-analysis
Article first published online: 28 DEC 2011
© 2011 The Authors. obesity reviews © 2011 International Association for the Study of Obesity
Volume 13, Issue 5, pages 456–468, May 2012
How to Cite
Backholer, K., Wong, E., Freak-Poli, R., Walls, H. L. and Peeters, A. (2012), Increasing body weight and risk of limitations in activities of daily living: a systematic review and meta-analysis. Obesity Reviews, 13: 456–468. doi: 10.1111/j.1467-789X.2011.00970.x
- Issue published online: 15 APR 2012
- Article first published online: 28 DEC 2011
- Received 25 October 2011; revised 8 November 2011; accepted 25 November 2011
- Activities of daily living;
- body mass index;
This study examined the relationship between normal weight, overweight and obesity class I and II+, and the risk of disability, which is defined as impairment in activities of daily living (ADL). Systematic searching of the literature identified eight cross-sectional studies and four longitudinal studies that were comparable for meta-analysis. An additional four cross-sectional studies and one longitudinal study were included for qualitative review. Results from the meta-analysis of cross-sectional studies revealed a graded increase in the risk of ADL limitations from overweight (1.04, 95% confidence interval [CI] 1.00–1.08), class I obesity (1.16, 95% CI 1.11–1.21) and class II+ obesity (1.76, 95% CI 1.28–2.41), relative to normal weight. Meta-analyses of longitudinal studies revealed a similar graded relationship; however, the magnitude of this relationship was slightly greater for all body mass index categories. Qualitative analysis of studies that met the inclusion criteria but were not compatible for meta-analysis supported the pooled results. No studies identified met all of the pre-defined quality criteria, and subgroup analysis was inhibited due to insufficient comparable studies. We conclude that increasing body weight increases the risk of disability in a graded manner, but also emphasize the need for additional studies using contemporary longitudinal cohorts with large numbers of obese class III individuals, a range of ages and with measured height and weight, and incident ADL questions.