This study was supported by grants from AA10079 and AA12277 from the National Institute of Alcohol Abuse and Alcoholism and the Wallace Research Foundation.
Sensory Processing Disorder in a Primate Model: Evidence From a Longitudinal Study of Prenatal Alcohol and Prenatal Stress Effects
Article first published online: 4 FEB 2008
© 2008 by the Society for Research in Child Development, Inc.
Volume 79, Issue 1, pages 100–113, January/February 2008
How to Cite
Schneider, M. L., Moore, C. F., Gajewski, L. L., Larson, J. A., Roberts, A. D., Converse, A. K. and DeJesus, O. T. (2008), Sensory Processing Disorder in a Primate Model: Evidence From a Longitudinal Study of Prenatal Alcohol and Prenatal Stress Effects. Child Development, 79: 100–113. doi: 10.1111/j.1467-8624.2007.01113.x
- Issue published online: 4 FEB 2008
- Article first published online: 4 FEB 2008
Disrupted sensory processing, characterized by over- or underresponsiveness to environmental stimuli, has been reported in children with a variety of developmental disabilities. This study examined the effects of prenatal stress and moderate-level prenatal alcohol exposure on tactile sensitivity and its relationship to striatal dopamine system function in thirty-eight 5- to 7-year-old rhesus monkeys. The monkeys were from four experimental conditions: (a) prenatal alcohol exposed, (b) prenatal stress, (c) prenatal alcohol exposed + prenatal stress, and (d) sucrose controls. Increased D2 receptor binding in the striatum, evaluated using positron emission tomography neuroimaging, was related to increased withdrawal (aversion) responses to repetitive tactile stimuli and reduced habituation across trials. Moreover, prenatal stress significantly increased overall withdrawal responses to repetitive tactile stimulation compared to no prenatal stress.