Epigenetics and the Biological Definition of Gene × Environment Interactions
Article first published online: 4 FEB 2010
© 2010, Copyright the Author(s). Journal Compilation © 2010, Society for Research in Child Development, Inc.
Volume 81, Issue 1, pages 41–79, January/February 2010
How to Cite
Meaney, M. J. (2010), Epigenetics and the Biological Definition of Gene × Environment Interactions. Child Development, 81: 41–79. doi: 10.1111/j.1467-8624.2009.01381.x
- Issue published online: 4 FEB 2010
- Article first published online: 4 FEB 2010
Variations in phenotype reflect the influence of environmental conditions during development on cellular functions, including that of the genome. The recent integration of epigenetics into developmental psychobiology illustrates the processes by which environmental conditions in early life structurally alter DNA, providing a physical basis for the influence of the perinatal environmental signals on phenotype over the life of the individual. This review focuses on the enduring effects of naturally occurring variations in maternal care on gene expression and phenotype to provide an example of environmentally driven plasticity at the level of the DNA, revealing the interdependence of gene and environmental in the regulation of phenotype.