We are indebted to participants of the Twins Early Development Study (TEDS) for making the study possible. The TEDS twin study was supported by a program grant MRC grant G0500079 from the UK Medical Research Council. P.B. was supported by the UK NIHR Biomedical Research Centre for Mental Health at the Institute of Psychiatry, Kings College London and The South London and Maudsley NHS Foundation Trust. A.R. was funded by an Autism Speaks fellowship.
Exploring the Relation Between Prenatal and Neonatal Complications and Later Autistic-Like Features in a Representative Community Sample of Twins
Version of Record online: 4 FEB 2010
© 2010, Copyright the Author(s). Journal Compilation © 2010, Society for Research in Child Development, Inc.
Volume 81, Issue 1, pages 166–182, January/February 2010
How to Cite
Ronald, A., Happé, F., Dworzynski, K., Bolton, P. and Plomin, R. (2010), Exploring the Relation Between Prenatal and Neonatal Complications and Later Autistic-Like Features in a Representative Community Sample of Twins. Child Development, 81: 166–182. doi: 10.1111/j.1467-8624.2009.01387.x
- Issue online: 4 FEB 2010
- Version of Record online: 4 FEB 2010
Prenatal and neonatal events were reported by parents of 13,690 eighteen-month-old twins enrolled in the Twins Early Development Study, a representative community sample born in England and Wales. At ages 7–8, parents and teachers completed questionnaires on social and nonsocial autistic-like features and parents completed the Childhood Asperger Syndrome Test. Correlations between prenatal and neonatal events and autistic-like features were weak, both in the whole sample (r = .00–.07) and at the 5% quantitative extreme (phenotypic group correlations = .01–.11), after controlling for socioeconomic status and cognitive ability. Neonatal problems showed modest heritability (13%–14%) and significant shared and nonshared environmental influences (55%–59% and 28%–31%, respectively). Differences in identical twins’ neonatal problems correlated weakly with their difference scores on autistic-like features (r = .01–.06).