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Figure S1. DNA methylation at a CpG site in the promoter of the MGMT gene was correlated with paternal stress during infancy in girls only.

Figure S2. DNA methylation at two CpG sites in the first exon of the c19orf30 gene was correlated with paternal stress during preschool in girls only.

Figure S3. DNA methylation at three CpG sites in the MGC33302 gene (also known as MFSD8/CLN7) was correlated with paternal stress during preschool in girls only.

Table S1. Correlation between maternal stress during infancy and increased DNA methylation in adolescence in full sample (all CpG sites with FDR < 20%). Sites with greater than 5% differential methylation are highlighted in gray.

Table S2. Correlation between paternal stress during preschool and increased DNA methylation in adolescence in full sample (all CpG sites with FDR < 20%). Sites with greater than 5% differential methylation are highlighted in gray.

Table S3. Correlation of parental stress during infancy and preschool with DNA methylation levels of selected candidate genes. FDR corresponds to the multiple testing correction applied to the entire data set (n = 18,231).

Table S4. Correlation between maternal stress during infancy and increased DNA methylation in adolescence in boys only (all CpG sites with FDR < 20%). Sites with greater than 5% differential methylation are highlighted in gray.

Table S5. Correlation between maternal stress during infancy and increased DNA methylation in adolescence in girls only (all CpG sites with FDR < 20%). Sites with greater than 5% differential methylation are highlighted in gray.

Table S6. Correlation between paternal stress during infancy and decreased DNA methylation in adolescence in girls only (all CpG sites with FDR < 20%). Sites with greater than 5% differential methylation are highlighted in gray.

Table S7. Correlation between paternal stress during preschool and increased DNA methylation in adolescence in girls only (all CpG sites with FDR < 20%). Sites with greater than 5% differential methylation are highlighted in gray.

Table S8. Comparison of correlations between paternal stress during preschool and increased DNA methylation in adolescence in full sample and girls only (limited to all CpG sites with FDR <20% from full sample). All sites with FDR < 20% in girls only are highlighted in gray.

Table S9. Correlation between paternal stress during preschool and decreased DNA methylation in girls only (all CpG sites with FDR < 20%). Sites with greater than 5% differential methylation are highlighted in gray.

Table S10. Genes with DNA methylation of more than 1 CpG site correlated with paternal stress during preschool in girls only (all CpG sites with FDR < 20%). Sites with greater than 5% differential methylation are highlighted in gray.

Table S11. DAVID analysis to determine GO term enrichment for genes whose DNA methylation level was correlated with maternal stress during infancy in the full sample. All CpG sites with FDR < 20% from Table  S2 were used for DAVID analysis.

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cdev1641_sm_figS1.pdf22KSupporting info item
cdev1641_sm_figS2.pdf13KSupporting info item
cdev1641_sm_figS3.pdf12KSupporting info item
cdev1641_sm_tableS1.pdf191KSupporting info item
cdev1641_sm_tableS10.pdf214KSupporting info item
cdev1641_sm_tableS11.pdf249KSupporting info item
cdev1641_sm_tableS2.pdf94KSupporting info item
cdev1641_sm_tableS3.pdf304KSupporting info item
cdev1641_sm_tableS4.pdf65KSupporting info item
cdev1641_sm_tableS5.pdf63KSupporting info item
cdev1641_sm_tableS6.pdf65KSupporting info item
cdev1641_sm_tableS7.pdf377KSupporting info item
cdev1641_sm_tableS8.pdf182KSupporting info item
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