We gratefully thank all the children and their families who were enrolled in this study, and all individuals who donated blood samples for research purposes. We also acknowledge the resources provided by the AGRE Consortium and participating families. We thank the technical staff at the Center for Applied Genomics at CHOP for producing the genotypes used for analyses, and the nursing, medical assistant and medical staff for their help with recruitment. All genotyping of the AGRE cohort was supported by an Institutional Development Award to the Center for Applied Genomics at the Children’s Hospital of Philadelphia. The study was supported in part by a Research Award from the Margaret Q. Landenberger Foundation, by the PA Department of Health (PADOH) grant for the CHOP/PENN Center for Excellence for Autism Research, and a Research Development Award from the Cotswold Foundation.
SPECIAL SECTION: GENOMICS
A Genome-Wide Association Study of Autism Incorporating Autism Diagnostic Interview–Revised, Autism Diagnostic Observation Schedule, and Social Responsiveness Scale
Article first published online: 30 AUG 2012
© 2012 The Authors. Child Development © 2012 Society for Research in Child Development, Inc.
Volume 84, Issue 1, pages 17–33, January/February 2013
How to Cite
Connolly, J. J., Glessner, J. T. and Hakonarson, H. (2013), A Genome-Wide Association Study of Autism Incorporating Autism Diagnostic Interview–Revised, Autism Diagnostic Observation Schedule, and Social Responsiveness Scale. Child Development, 84: 17–33. doi: 10.1111/j.1467-8624.2012.01838.x
- Issue published online: 25 JAN 2013
- Article first published online: 30 AUG 2012
Appendix S1. Genotype Statistical Analysis.
Appendix S2. Clinical Value Distribution ofSignificant SNPs for Three Genotype States in (A) Scatter PlotCounts and (B) Box Plots.
Appendix S3. p-Values for Other ADI-R,ADOS, and SRS Clinical Variables That Did Not Approach ThresholdLevels.
Appendix S4. (A) QQ Plot Combined All SNPsAcross All Clinical Variables p-Valuesn = 61,090,625. (B) Individual QQ Plots for EachClinical Variable.
Appendix S5. Main Overall Transmission Disequilibrium Test Association of AGRE 1,549 affected offspring trios for Significant Clinical Variable Associations
Appendix S6. Associations Between Assessment Items and SNPs Identified by Wang et al. (2009).
Appendix S7. GWA-Significant Items Broken-Down by Endorsement Score.
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