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Appendix S1. Genotype Statistical Analysis.

Appendix S2. Clinical Value Distribution ofSignificant SNPs for Three Genotype States in (A) Scatter PlotCounts and (B) Box Plots.

Appendix S3. p-Values for Other ADI-R,ADOS, and SRS Clinical Variables That Did Not Approach ThresholdLevels.

Appendix S4. (A) QQ Plot Combined All SNPsAcross All Clinical Variables p-Valuesn = 61,090,625. (B) Individual QQ Plots for EachClinical Variable.

Appendix S5. Main Overall Transmission Disequilibrium Test Association of AGRE 1,549 affected offspring trios for Significant Clinical Variable Associations

Appendix S6. Associations Between Assessment Items and SNPs Identified by Wang et al. (2009).

Appendix S7. GWA-Significant Items Broken-Down by Endorsement Score.

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