This study looks at 400 technology transfer disclosures and their inventors over a 10-year period at a large US research university. We find that faculty productivity in terms of patenting is not related to commercialization success, but entrepreneurial qualities are significantly correlated. Results indicate that the significant factors in successfully forming a university spin-out are the level of experience of the faculty member and participation in an industry sponsored research agreement. We also find that the academic inventor's entrepreneurial experience and inclination toward commercialization have the most positive impacts on the formation of a new venture.