Can a technological culture accommodate spiritual experience and spiritual thinking? If so, what kind of spirituality? I explore the relation between technology and spirituality by constructing and discussing several models for spirituality in a technological culture. I show that although gnostic and animistic interpretations and responses to technology are popular challenges to secularization and disenchantment claims, both the Christian tradition and contemporary posthumanist theory provide interesting alternatives to guide our spiritual experiences and thinking in a technological culture. I analyze how creational, network, and cyborg metaphors defy suggestions of (individual) animation or alienation and instead offer different ways of conceptualizing and experiencing communion between the material and the spiritual.