*Members of the study group are listed in the Appendix A.
Loss to follow-up in an international, multicentre observational study
Article first published online: 7 APR 2008
© 2008 British HIV Association
Volume 9, Issue 5, pages 261–269, May 2008
How to Cite
Mocroft, A., Kirk, O., Aldins, P., Chies, A., Blaxhult, A., Chentsova, N., Vetter, N., Dabis, F., Gatell, J., Lundgren, J. and for the EuroSIDA study group (2008), Loss to follow-up in an international, multicentre observational study. HIV Medicine, 9: 261–269. doi: 10.1111/j.1468-1293.2008.00557.x
- Issue published online: 7 APR 2008
- Article first published online: 7 APR 2008
- Received: 9 January 2008, accepted 22 January 2008
- loss to follow-up;
- vital status
The aim of this work was to assess loss to follow-up (LTFU) in EuroSIDA, an international multicentre observational cohort study.
LTFU was defined as no follow-up visit, CD4 cell count measurement or viral load measurement after 1 January 2006. Poisson regression was used to describe factors related to LTFU.
The incidence of LTFU in 12 304 patients was 3.72 per 100 person-years of follow-up [95% confidence interval (CI) 3.58–3.86; 2712 LTFU] and varied among countries from 0.67 to 13.35. After adjustment, older patients, those with higher CD4 cell counts, and those who had started combination antiretroviral therapy all had lower incidences of LTFU, while injecting drug users had a higher incidence of LTFU. Compared with patients from Southern Europe and Argentina, patients from Eastern Europe had over a twofold increased incidence of LTFU after adjustment (incidence rate ratio 2.16; 95% CI 1.84–2.53; P<0.0001). A total of 2743 patients had a period of >1 year with no CD4 cell count or viral load measured during the year; 743 (27.1%) subsequently returned to follow-up.
Some patients thought to be LTFU may have died, and efforts should be made to ascertain vital status wherever possible. A significant proportion of patients who have a year with no follow-up visit, CD4 cell count measurement or viral load measurement subsequently return to follow-up.