*GERMIVIC, Joint Study Group on Hepatitis C Virus of the French National Society of Internal Medicine and the French Society of Infectious Diseases (see Appendix A); ANRS, Agence Nationale de Recherche sur le SIDA. Data were presented previously at the 58th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, 2–6 November 2007 and published as an abstract in Hepatology 2007; 46: 296A (Abstract 135).
Liver-related deaths in HIV-infected patients between 1995 and 2005 in the French GERMIVIC Joint Study Group Network (Mortavic 2005 Study in collaboration with the Mortalité 2005 survey, ANRS EN19)*
Version of Record online: 15 FEB 2009
© 2009 British HIV Association
Volume 10, Issue 5, pages 282–289, May 2009
How to Cite
Rosenthal, E., Salmon-Céron, D., Lewden, C., Bouteloup, V., Pialoux, G., Bonnet, F., Karmochkine, M., May, T., François, M., Burty, C., Jougla, E., Costagliola, D., Morlat, P., Chêne, G., Cacoub, P. and the Mortavic/Mortalité 2005 Study Group (2009), Liver-related deaths in HIV-infected patients between 1995 and 2005 in the French GERMIVIC Joint Study Group Network (Mortavic 2005 Study in collaboration with the Mortalité 2005 survey, ANRS EN19). HIV Medicine, 10: 282–289. doi: 10.1111/j.1468-1293.2008.00686.x
- Issue online: 16 APR 2009
- Version of Record online: 15 FEB 2009
- Accepted 31 October 2008
- hepatitis C virus;
- hepatocellular carcinoma;
More than 10 years after the introduction of combination antiretroviral therapy (cART), we examined the trend in the proportion of deaths caused by end-stage liver disease (ESLD) in HIV-infected adults in France between 1995 and 2005.
Design and methods
In 2005, 34 departments prospectively recorded all deaths in HIV-infected patients who were followed in those departments (around 24 000). Results were compared with those of four previous cross-sectional surveys conducted since 1995 using the same methodology.
Among 287 reported deaths in 2005, 100 (35%) were related to AIDS, and 48 (17%) to ESLD. Three out of four patients who died from ESLD-related causes had chronic hepatitis C. Excessive alcohol consumption was reported in approximately half of the patients (48%). At death, 62% of patients had undetectable HIV viral load and the median CD4 count was 237 cells/μL. From 1995 to 2005, the proportion of deaths caused by ESLD increased from 2 to 17% (P<0.001). The proportion of deaths caused by hepatocellular carcinoma increased from 5% in 1995 to 25% in 2005 (P=0.0337).
Over the 10 years from 1995 to 2005, the proportion of deaths caused by hepatitis C virus-related ESLD has increased in HIV-infected patients. ESLD is currently a leading cause of death in this population, with hepatocellular carcinoma representing a quarter of liver-related deaths. Recommendations for the detection of hepatocellular carcinoma should be strictly applied in these patients.