Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites
Article first published online: 21 MAR 2010
© 2010 British HIV Association
Volume 11, Issue 9, pages 554–564, October 2010
How to Cite
Belloso, W., Orellana, L., Grinsztejn, B., Madero, J., La Rosa, A., Veloso, V., Sanchez, J., Ismerio Moreira, R., Crabtree-Ramirez, B., Garcia Messina, O., Lasala, M., Peinado, J. and Losso, M. (2010), Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites. HIV Medicine, 11: 554–564. doi: 10.1111/j.1468-1293.2010.00824.x
- Issue published online: 3 SEP 2010
- Article first published online: 21 MAR 2010
- Accepted 17 December 2009
- cardiovascular disease;
- CD4 cell lymphocyte count;
- cohort studies;
- liver diseases;
Acquired immune deficiency appears to be associated with serious non-AIDS (SNA)-defining conditions such as cardiovascular disease, liver and renal insufficiency and non-AIDS-related malignancies. We analysed the incidence of, and factors associated with, several SNA events in the LATINA retrospective cohort.
Materials and methods
Cases of SNA events were recorded among cohort patients. Three controls were selected for each case from cohort members at risk. Conditional logistic models were fitted to estimate the effect of traditional risk factors as well as HIV-associated factors on non-AIDS-defining conditions.
Among 6007 patients in follow-up, 130 had an SNA event (0.86 events/100 person-years of follow-up) and were defined as cases (40 with cardiovascular events, 54 with serious liver failure, 35 with non-AIDS-defining malignancies and two with renal insufficiency). Risk factors such as diabetes, hepatitis B and C virus coinfections and alcohol abuse showed an association with events, as expected. The last recorded CD4 T-cell count prior to index date (P=0.0056, with an average difference of more than 100 cells/μL) and area under the CD4 cell curve in the year previous to index date (P=0.0081) were significantly lower in cases than in controls. CD4 cell count at index date was significantly associated with the outcome after adjusting for risk factors.
The incidence and type of SNA events found in this Latin American cohort are similar to those reported in other regions. We found a significant association between immune deficiency and the risk of SNA events, even in patients under antiretroviral treatment.