Cognitive function after several years of antiretroviral therapy with stable central nervous system penetration score

Authors

  • Y Kahouadji,

    1. Internal Medicine A, Groupe Hospitalier Lariboisière-Fernand Widal-Saint Louis, APHP, Université Paris VII, Paris, France
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  • J Dumurgier,

    1. Centre Mémoire de Ressources et de Recherche (CMRR), Groupe Hospitalier Lariboisière-Fernand Widal-Saint Louis, APHP, Université Paris VII, Paris, France
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  • P Sellier,

    1. Internal Medicine A, Groupe Hospitalier Lariboisière-Fernand Widal-Saint Louis, APHP, Université Paris VII, Paris, France
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  • P Lapalus,

    1. Centre Mémoire de Ressources et de Recherche (CMRR), Groupe Hospitalier Lariboisière-Fernand Widal-Saint Louis, APHP, Université Paris VII, Paris, France
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  • V Delcey,

    1. Internal Medicine A, Groupe Hospitalier Lariboisière-Fernand Widal-Saint Louis, APHP, Université Paris VII, Paris, France
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  • JF Bergmann,

    1. Internal Medicine A, Groupe Hospitalier Lariboisière-Fernand Widal-Saint Louis, APHP, Université Paris VII, Paris, France
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  • J Hugon,

    1. Centre Mémoire de Ressources et de Recherche (CMRR), Groupe Hospitalier Lariboisière-Fernand Widal-Saint Louis, APHP, Université Paris VII, Paris, France
    2. INSERM U839 Institut du Fer à Moulin, Paris, France
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  • C Paquet

    Corresponding author
    1. INSERM U839 Institut du Fer à Moulin, Paris, France
    • Centre Mémoire de Ressources et de Recherche (CMRR), Groupe Hospitalier Lariboisière-Fernand Widal-Saint Louis, APHP, Université Paris VII, Paris, France
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Correspondence: Dr Claire Paquet, Centre Mémoire de Ressources et de Recherche, Groupe Hospitalier Lariboisière-Fernand Widal-Saint Louis, 200 rue du Faubourg Saint-Denis, 75010 Paris, France. Tel: +3301400554954; fax: +330149958495; e-mail: claire.paquet@inserm.fr

Abstract

Objectives

Previous studies in HIV-infected populations have yielded conflicting results on the effect of antiretroviral therapy (ART) on cognition. Our objective was to investigate the effect of several years of ART with stable central nervous system penetration effectiveness (CPE) score on neuropsychological performance in HIV-infected individuals.

Methods

We analysed a clinical cohort of HIV-infected patients who initiated ART between June 2003 and December 2006 and maintained stable CPE scores. Patients were evaluated with a short neuropsychological battery. Using linear regression, we examined the relationship between results of cognitive tests and CPE scores in all patients.

Results

Patients were divided into three similarly sized groups (CPE ≤ 1, CPE between 1.5 and 2.5, and CPE ≥ 2.5). We found that ART with high CPE scores was associated with poorer executive performances in HIV-1-infected patients.

Conclusion

These results suggest that cognitive performance in treated HIV-infected patients could be influenced by ART.

Ancillary