Human photosensitivity: from pathophysiology to treatment
Article first published online: 20 OCT 2005
European Journal of Neurology
Volume 12, Issue 11, pages 828–841, November 2005
How to Cite
Verrotti, A., Tocco, A. M., Salladini, C., Latini, G. and Chiarelli, F. (2005), Human photosensitivity: from pathophysiology to treatment. European Journal of Neurology, 12: 828–841. doi: 10.1111/j.1468-1331.2005.01085.x
- Issue published online: 20 OCT 2005
- Article first published online: 20 OCT 2005
- Received 5 September 2004 Accepted 9 November 2004
- antiepileptic drugs;
- intermittent photic stimulation;
- photo paroxysmal response;
- visual induced seizures;
- visual stimuli
Photosensitivity is a condition detected on the electroencephalography (EEG) as a paroxysmal reaction to Intermittent Photic Stimulation (IPS). This EEG response, elicited by IPS or by other visual stimuli of daily life, is called Photo Paroxysmal Response (PPR). PPRs are well documented in epileptic and non-epileptic subjects. Photosensitivity rarely in normal individuals evolves into epilepsy. Photosensitive epilepsy is a rare refex epilepsy characterized by seizures in photosensitive individuals.
The development of modern technology has increased the exposition to potential seizure precipitants in people of all ages, but especially in children and adolescents. Actually, videogames, computers and televisions are the most common triggers in daily life of susceptible persons.
The mechanisms of generation of PPR are poorly understood, but genetic factors play an important rule.
The control of visually induced seizures has, generally a good prognosis. In patients known to be visually sensitive, avoidance of obvious source and stimulus modifications are very important and useful to seizure prevention, but in the large majority of patients with epilepsy and photosensitivity antiepileptic drugs are needed.