PM and BB contributed equally.
High-fat diet impairs hippocampal neurogenesis in male rats
Version of Record online: 13 NOV 2006
European Journal of Neurology
Volume 13, Issue 12, pages 1385–1388, December 2006
How to Cite
Lindqvist, A., Mohapel, P., Bouter, B., Frielingsdorf, H., Pizzo, D., Brundin, P. and Erlanson-Albertsson, C. (2006), High-fat diet impairs hippocampal neurogenesis in male rats. European Journal of Neurology, 13: 1385–1388. doi: 10.1111/j.1468-1331.2006.01500.x
- Issue online: 13 NOV 2006
- Version of Record online: 13 NOV 2006
- Received 13 September 2005 Accepted 12 December 2005
- fat intake;
High fat diets and obesity pose serious health problems, such as type II diabetes and cardiovascular disease. Impaired cognitive function is also associated with high fat intake. In this study, we show that just 4 weeks of feeding a diet rich in fat ad libitum decreased hippocampal neurogenesis in male, but not female, rats. There was no obesity, but male rats fed a diet rich in fat exhibited elevated serum corticosterone levels compared with those fed standard rat chow. These data indicate that high dietary fat intake can disrupt hippocampal neurogenesis, probably through an increase in serum corticosterone levels, and that males are more susceptible than females.