Review of the therapeutic management of Parkinson's disease. Report of a joint task force of the European Federation of Neurological Societies (EFNS) and the Movement Disorder Society-European Section (MDS-ES). Part II: late (complicated) Parkinson's disease

  1. M. Horstink1,
  2. E. Tolosa2,
  3. U. Bonuccelli3,
  4. G. Deuschl4,
  5. A. Friedman5,
  6. P. Kanovsky6,
  7. J. P. Larsen7,
  8. A. Lees8,
  9. W. Oertel9,
  10. W. Poewe10,
  11. O. Rascol11,
  12. C. Sampaio12

Article first published online: 12 JUN 2006

DOI: 10.1111/j.1468-1331.2006.01548.x

Issue

European Journal of Neurology

European Journal of Neurology

Volume 13, Issue 11, pages 1186–1202, November 2006

Additional Information

How to Cite

Horstink, M., Tolosa, E., Bonuccelli, U., Deuschl, G., Friedman, A., Kanovsky, P., Larsen, J. P., Lees, A., Oertel, W., Poewe, W., Rascol, O. and Sampaio, C. (2006), Review of the therapeutic management of Parkinson's disease. Report of a joint task force of the European Federation of Neurological Societies (EFNS) and the Movement Disorder Society-European Section (MDS-ES). Part II: late (complicated) Parkinson's disease. European Journal of Neurology, 13: 1186–1202. doi: 10.1111/j.1468-1331.2006.01548.x

Author Information

  1. 1

    Department of Neurology, Radboud University Medical Centre, Nijmegen, The Netherlands

  2. 2

    Neurology Service, Hospital Clínic, Universitat de Barcelona, Spain

  3. 3

    Department of Neurosciences, University of Pisa, Italy

  4. 4

    Department of Neurology, Christian-Albrechts-University Kiel, Germany

  5. 5

    Department of Neurology, Medical University of Warsaw, Poland

  6. 6

    Department of Neurology, Palacky University, Olomouc, Czech Republic

  7. 7

    Department of Neurology, Stavanger University Hospital, Norway

  8. 8

    Reta Lila Weston Institute of Neurological Studies, London, UK

  9. 9

    Philipps-University of Marburg, Centre of Nervous Diseases, Marburg, Germany

  10. 10

    Department of Neurology, Innsbruck Medical University, Austria

  11. 11

    Clinical Investigation Centre, Departments of Clinical Pharmacology and Neurosciences, University Hospital, Toulouse, France

  12. 12

    Laboratório de Farmacologia Clinica e Terapeutica e Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Portugal

*Dr M. W. I. M. Horstink, Department of Neurology, Radboud University Medical Centre, P.O Box 9101, 6500 HB Nijmegen, The Netherlands (tel.: +31 24 361 5202; fax: +31 24 354 1122; e-mail: m.horstink@neuro.umcn.nl).

Publication History

  1. Issue published online: 13 OCT 2006
  2. Article first published online: 12 JUN 2006
  3. Received 8 March 2006 Accepted 13 March 2006

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Keywords:

  • management guideline;
  • neurosurgery;
  • Parkinson's disease;
  • pharmacotherapy;
  • review

To provide evidence-based recommendations for the management of late (complicated) Parkinson's disease (PD), based on a review of the literature. Complicated PD refers to patients suffering from the classical motor syndrome of PD along with other motor or non-motor complications, either disease-related (e.g. freezing) or treatment-related (e.g. dyskinesias or hallucinations). MEDLINE, Cochrane Library and INAHTA database literature searches were conducted. National guidelines were requested from all EFNS societies. Non-European guidelines were searched for using MEDLINE. Part II of the guidelines deals with treatment of motor and neuropsychiatric complications and autonomic disturbances. For each topic, a list of therapeutic interventions is provided, including classification of evidence. Following this, recommendations for management are given, alongside ratings of efficacy. Classifications of evidence and ratings of efficacy are made according to EFNS guidance. In cases where there is insufficient scientific evidence, a consensus statement (‘good practice point’) is made.

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