Cerebral atrophy in Parkinson's disease patients with visual hallucinations

Authors

  • B. Ramírez-Ruiz,

    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    2. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
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  • M.-J. Martí,

    1. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
    2. Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Barcelona, Spain
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  • E. Tolosa,

    1. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
    2. Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Barcelona, Spain
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  • M. Giménez,

    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    2. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
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  • N. Bargalló,

    1. Radiology Department, Centre de Diagnòstic per la Imatge (CDI), Hospital Clínic de Barcelona, Barcelona, Spain
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  • F. Valldeoriola,

    1. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
    2. Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Barcelona, Spain
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  • C. Junqué

    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    2. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
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Carme Junqué, Departament de Psiquiatria i Psicobiologia Clinica, Facultat de Medicina, Universitat de Barcelona, Casanova, 143, 08036 Barcelona, Spain (tel.: +34 93 402 45 70; fax: +34 93 403 52 94; e-mail: cjunque@ub.edu).

Abstract

Although visual hallucinations (VH) are relatively frequent in Parkinson's disease (PD) patients, their neural substrates are only known from neuropathological and functional magnetic resonance studies. The aim of this study was to investigate possible structural brain changes on MRI in non-demented PD patients with VH using voxel-based morphometry. Eighteen PD patients with VH were compared to 20 patients with PD without VH and 21 healthy controls. Compared with both controls and the non-hallucinating PD group, PD patients with VH had grey matter volume reductions in the lingual gyrus and superior parietal lobe. Structural changes in these areas involved in higher visual processing may be important in understanding the VH and visual deficits in PD patients.

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