A comparison of cerebral glucose metabolism in Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies
Article first published online: 18 OCT 2007
European Journal of Neurology
Volume 14, Issue 12, pages 1357–1362, December 2007
How to Cite
Yong, S. W., Yoon, J. K., An, Y. S. and Lee, P. H. (2007), A comparison of cerebral glucose metabolism in Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies. European Journal of Neurology, 14: 1357–1362. doi: 10.1111/j.1468-1331.2007.01977.x
- Issue published online: 18 OCT 2007
- Article first published online: 18 OCT 2007
- Received 17 June 2007 Accepted 13 September 2007
- cerebral glucose metabolism;
- dementia with Lewy bodies;
- Parkinson's disease;
- Parkinson's disease dementia
Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) share many similar aspects, and making a clinical diagnosis of one disorder over the other relies heavily on an arbitrary criterion, so-called 1-year rule. This study was designed to search for any difference of metabolic patterns in these two disorders using F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) images.
We enrolled 16 patients with PD, 13 patients with PDD, and seven patients with DLB. FDG PET was performed, and images were reconstructed by iterative reconstruction using the computed tomography (CT) images, and were normalized to a standard template. Statistical comparison between groups were performed on a voxel-by-voxel basis using t-statistics (two-sample t-test).
Compared with the patients with PD, both PDD and DLB patients showed similar patterns of decreased metabolism in bilateral inferior and medial frontal lobes, and right parietal lobe (Puncorrected < 0.001). In a direct comparison, DLB patients had significant metabolic decrease (puncorrected < 0.005) in the anterior cingulate compared with those with PDD. These findings support the concept that PDD and DLB have similar underlying neurobiological characteristics, and that they can be regarded as a spectrum of Lewy body disorders.