This is a Continuing Medical Education article, and can be found with corresponding questions on the Internet at http://www.efns.org/content.php?pid=132. Certificates for correctly answering the questions will be issued by the EFNS.
EFNS guideline on diagnosis and management of limb girdle muscular dystrophies
Version of Record online: 15 NOV 2007
European Journal of Neurology
Volume 14, Issue 12, pages 1305–1312, December 2007
How to Cite
Norwood, F., De Visser, M., Eymard, B., Lochmüller, H. and Bushby, K. (2007), EFNS guideline on diagnosis and management of limb girdle muscular dystrophies. European Journal of Neurology, 14: 1305–1312. doi: 10.1111/j.1468-1331.2007.01979.x
- Issue online: 15 NOV 2007
- Version of Record online: 15 NOV 2007
- Received 5 September 2007 Accepted 10 September 2007
- limb girdle muscular dystrophies;
The limb girdle muscular dystrophies (LGMD) are termed as such as they share the characteristic feature of muscle weakness predominantly affecting the shoulder and pelvic girdles; their classification has been completely revised in recent years because of elucidation of many of the underlying genetic and protein alterations in the various subtypes. An array of diagnostic measures is possible but with varying ease of use and availability. Several aspects of muscle cell function appear to be involved in the causation of muscle pathology. These cellular variations may confer some specific clinical features thus permitting recognition of the LGMD subtype and hence directing appropriate levels of monitoring and intervention. Despite an extensive literature on the individual limb girdle dystrophies, these publications may be impenetrable for the general neurologist in this increasingly complex field. The proposed guidelines suggest an approach to the diagnosis and monitoring of the limb girdle dystrophies in a manner accessible to general neurologists.