Quantitation of non-motor symptoms in Parkinson’s disease
Article first published online: 12 AUG 2008
© 2008 The Author(s). Journal compilation © 2008 EFNS
European Journal of Neurology
Special Issue: Dopamine Agonists in Parkinson’s Disease - Focus on Non-motor Symptoms
Volume 15, Issue Supplement s2, pages 2–8, September 2008
How to Cite
Chaudhuri, K. R. and Martinez-Martin, P. (2008), Quantitation of non-motor symptoms in Parkinson’s disease. European Journal of Neurology, 15: 2–8. doi: 10.1111/j.1468-1331.2008.02212.x
- Issue published online: 12 AUG 2008
- Article first published online: 12 AUG 2008
- Received 14 December 2007 Accepted 16 March 2008
- non-motor symptoms;
- Parkinson’s disease;
Background: Disabling non-motor symptoms (NMS) associated with Parkinson’s disease (PD), such as dementia and loss of balance, do not respond well to levodopa therapy and can lead to eventual death in patients with the disease. In 2006, a multidisciplinary group of experts and patient representatives developed an NMS screening questionnaire (NMSQuest) and a unified Non-Motor Symptoms Scale (NMSS) to address the need for simple identification and comprehensive assessment of NMS in patients with PD.
Methods and Results: An international pilot study of 96 healthy controls and 123 patients with various stages of treated and untreated PD was conducted to demonstrate that the NMSQuest is a feasible, valid, and accepted tool.
Conclusion: The majority of patients and caregivers felt that the questionnaire was clear and relevant to their daily lives. Data from 242 PD patients with no dementia were analysed in a pilot study on the clinimetric validation of NMSS. Similar to the NMSQuest study, the NMSS study revealed a significant correlation between progression of PD and increasing NMS burden. These studies suggest that the NMSQuest accurately detects the NMS, and that the NMSS closely correlates with quality of life for PD patients.