Impact of neurological and medical complications on 3-month outcomes in acute ischaemic stroke
Article first published online: 17 OCT 2008
© 2008 The Author(s). Journal compilation © 2008 EFNS
European Journal of Neurology
Volume 15, Issue 12, pages 1324–1331, December 2008
How to Cite
Hong, K.-S., Kang, D.-W., Koo, J.-S., Yu, K.-H., Han, M.-K., Cho, Y.-J., Park, J.-M., Bae, H.-J. and Lee, B.-C. (2008), Impact of neurological and medical complications on 3-month outcomes in acute ischaemic stroke. European Journal of Neurology, 15: 1324–1331. doi: 10.1111/j.1468-1331.2008.02310.x
- Issue published online: 12 NOV 2008
- Article first published online: 17 OCT 2008
- Received 28 April 2008 Accepted 5 August 2008
- acute ischaemic stroke;
Objective: To evaluate the impact of neurological and medical complications on 3-month outcomes in acute ischaemic stroke patients.
Methods: We prospectively investigated complications for all the consecutive acute ischaemic stroke patients admitted within 7 days from onset in four university hospitals during a 1-year period. Baseline data and 3-month outcomes were collected. Poor outcome was defined as a modified Rankin Scale score 3–6.
Results: A total of 1 254 patients were recruited: 264 (21.1%) and 303 (24.2%) patients experienced one or more neurological and medical complications, respectively. The most common complications were ischaemic stroke progression (17.1%) and pneumonia (12.0%). Of 1 233 patients with available 3-month outcomes, 34.9% had a poor outcome. Multivariate analysis revealed that neurological (odds ratio, 95% confidence interval; 5.47, 3.63–8.24) and medical (3.47, 2.30–5.23) complications were independent predictors of the poor outcome. For the individual complications, ischaemic stroke progression (7.48, 4.73–11.84), symptomatic hemorrhagic transformation (3.57, 1.33–9.54), pneumonia (4.44, 2.20–8.99), extracranial bleeding (4.45, 1.88–10.53), and urinary tract infection (2.72, 1.32–5.60) were independently associated with the poor outcome.
Conclusion: Outcome after ischaemic stroke is adversely influenced by complications, especially ischaemic stroke progression, symptomatic hemorrhagic transformation, pneumonia, extracranial bleeding, and urinary tract infection. Interventions to prevent those complications might improve ischaemic stroke outcome.