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The coding-synonymous polymorphism rs1045280 (Ser280Ser) in β-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia

Authors


Dr I.-C. Lai, Department of Psychiatry, Yuli Veterans Hospital, No. 91, Shin-Shin St, Yuli, Hualien 981, Taiwan (tel.: +886 3 8883141 ext. 475; fax: +886 3 8887091; e-mail: lai_0228@yahoo.com.tw).

Abstract

Background:  Tardive dyskinesia (TD) is a severe and potentially irreversible adverse effect of long-term antipsychotic treatment. Typical antipsychotics are commonly binding to the dopamine receptor D2 (DRD2), but the occurrence of antipsychotic-induced TD is rather delayed; therefore, the development of TD may be associated with mediators or signalling complexes behind DRD2, such as β-arrestin 2 (ARRB2), an important mediator between DRD2 and serine–threonine protein kinase (AKT) signal cascade.

Methods:  A case–control study to evaluate the association between rs1045280 (Ser280Ser) and antipsychotic-induced TD was performed amongst 381 patients (TD/non-TD = 228/153).

Results:  There was a significant difference in the genotype distribution between TD and non-TD groups (= 0.025); furthermore, the allelic analysis indicated that patients with T allele had increased risk of TD occurrence (ORT = 1.58, 95% CI = 1.14–2.19, = 0.007).

Conclusions:  To the best of our knowledge, this is the first study reporting a positive association between the SNP rs1045280 and TD in schizophrenic patients.

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