The beneficial effect of statins treatment by stroke subtype
Article first published online: 25 NOV 2008
© 2008 The Author(s). Journal compilation © 2008 EFNS
European Journal of Neurology
Volume 16, Issue 1, pages 127–133, January 2009
How to Cite
Martínez-Sánchez, P., Rivera-Ordóñez, C., Fuentes, B., Ortega-Casarrubios, M. A., Idrovo, L. and Díez-Tejedor, E. (2009), The beneficial effect of statins treatment by stroke subtype. European Journal of Neurology, 16: 127–133. doi: 10.1111/j.1468-1331.2008.02370.x
- Issue published online: 8 DEC 2008
- Article first published online: 25 NOV 2008
- Received 26 May 2008 Accepted 17 October 2008
- acute stroke;
- atherothrombotic infarction;
- lacunar infarction;
Background and purpose: Statins have shown some protective effect after ischaemic stroke in observational studies. However, this effect has never been assessed by etiological subtypes.
Methods: Observational study using data from the Stroke Unit Data Bank from consecutive patients with cerebral infarction. Variables analyzed: demographic data, cardiovascular risk factors, treatment with statins at stroke onset, stroke severity, stroke subtype, in-hospital complications, length of stay, and functional status at discharge (modified Rankin Scale).
Results: A total of 2742 patients were included, 1539 were men. Mean age was 69.17 years (SD 12.19). Of these, 281 patients (10.2%) were receiving statins when admitted. The logistic regression analyses showed that previous treatment with statins was an independent predictor for better outcome at discharge among all strokes (OR, 2.08; 95% CI, 1.39 to 3.1) as well as for the atherothrombotic (OR, 2.79; 95% CI, 1.33 to 5.84) and lacunar strokes (OR, 2.28; 95% CI, 1.15 to 4.52) after adjustment for demographic data, risk factors, previous treatments, stroke subtypes, stroke severity, in-hospital complications and length of stay. This benefit was not observed either in cardioembolic or in other etiology strokes.
Conclusions: Previous treatment with statins is an independent factor associated with good outcomes in patients with ischaemic stroke. Atherothrombotic and small vessel strokes show the greatest benefit.