Outcome predictors, efficacy and safety of Botox and Dysport in the long-term treatment of hemifacial spasm
Article first published online: 15 JAN 2009
© 2009 The Author(s). Journal compilation © 2009 EFNS
European Journal of Neurology
Volume 16, Issue 3, pages 392–398, March 2009
How to Cite
Bentivoglio, A. R., Fasano, A., Ialongo, T., Soleti, F., Lo Fermo, S. and Albanese, A. (2009), Outcome predictors, efficacy and safety of Botox and Dysport in the long-term treatment of hemifacial spasm. European Journal of Neurology, 16: 392–398. doi: 10.1111/j.1468-1331.2008.02507.x
- Issue published online: 5 FEB 2009
- Article first published online: 15 JAN 2009
- Received 15 July 2008 Accepted 20 October 2008
- botulinum neurotoxin;
- hemifacial spasm;
Background and purpose: To review the clinical characteristics and the long-term outcome of patients with hemifacial spasm (HFS) who received botulinum neurotoxin (BoNT) over the past 10 years.
Results: A total of 108 patients received 665 treatments. Mean latency of clinical effect was 5.4 ± 5.3 days for Botox and 4.9 ± 4.6 days for Dysport (P > 0.05). Mean duration of clinical improvement was higher after the injection of Dysport than Botox: 105.9 ± 54.2 and 85.4 ± 41.6 days respectively (P < 0.01). The percentage of treatment failures was 6.5% for Botox and 4.6% for Dysport (P > 0.05). The doses of Botox significantly increased over time (β = 0.35, P < 0. 001) whilst Dysport dose remained unchanged (β = 0.16, n.s.). The duration of clinical benefit slightly increased with Botox (β = 0.12; P < 0.01), but remained constant for Dysport. Side effects occurred in 17.4% of treatments: 16.7% of patients who had received Botox, and in 19.7% who had received Dysport (P > 0.05). The most common side effects were palpebral ptosis and lacrimation; ptosis and lagophtalmos was more common in Dysport treatments (P < 0.005).
Conclusions: Both brands are effective and safe in treating HFS; efficacy is long-lasting. The differences in outcome and side effects confirm that, albeit the active drug is the same, Botox and Dysport should be considered as two different drugs.