Cerebral white matter hyperintensities are not increased in patients with primary Sjögren’s syndrome
Article first published online: 11 FEB 2009
© 2009 The Author(s). Journal compilation © 2009 EFNS
European Journal of Neurology
Volume 16, Issue 5, pages 576–581, May 2009
How to Cite
Harboe, E., Beyer, M. K., Greve, O. J., Gøransson, L. G., Tjensvoll, A. B., Kvaløy, J. T. and Omdal, R. (2009), Cerebral white matter hyperintensities are not increased in patients with primary Sjögren’s syndrome. European Journal of Neurology, 16: 576–581. doi: 10.1111/j.1468-1331.2009.02537.x
- Issue published online: 15 APR 2009
- Article first published online: 11 FEB 2009
- Received 26 August 2008 Accepted 12 December 2008
- cerebral MRI;
- controlled study;
- Sjögren’s syndrome;
- white matter
Background and purpose: It is frequently thought that cerebral white matter hyperintensities (WMHs) on T-2 weighted MRI scans are increased in patients with autoimmune diseases. An increased frequency of WHMs has been described in primary Sjögren’s syndrome (PSS), but no controlled studies exist. The aim of this study was therefore to compare WMHs in PSS patients and healthy subjects applying the new European-American criteria for PSS.
Methods: Cross-sectional controlled study of 68 unselected PSS patients and 68 healthy subjects was carried out. WMHs were rated using Scheltens method.
Results: There were no differences in total or any regional WMH scores between PSS patients and healthy subjects.
Conclusions: Patients with PSS do not have increased WMH load or distribution when compared with healthy subjects.