Both authors have contributed equally.
Revascularization in acute ischaemic stroke using the penumbra system: the first single center experience
Article first published online: 29 JUL 2009
© 2009 The Author(s). Journal compilation © 2009 EFNS
European Journal of Neurology
Volume 16, Issue 11, pages 1210–1216, November 2009
How to Cite
Grunwald, I. Q., Walter, S., Papanagiotou, P., Krick, C., Hartmann, K., Dautermann, A., Faßbender, K., Haass, A., Bolar, L. J., Reith, W. and Roth, C. (2009), Revascularization in acute ischaemic stroke using the penumbra system: the first single center experience. European Journal of Neurology, 16: 1210–1216. doi: 10.1111/j.1468-1331.2009.02750.x
- Issue published online: 15 OCT 2009
- Article first published online: 29 JUL 2009
- Received 6 November 2008 Accepted 29 April 2009
- acute ischaemic stroke;
- mechanical thrombectomy;
Background and purpose: This is the first single center experience illustrating the effectiveness of the penumbra system (PS) in the treatment of large vessel occlusive disease in the arena of acute ischaemic stroke. The PS is an innovative mechanical thrombectomy device, employed in the revascularization of large cerebral vessel occlusions in patients via the utilization of an aspiration platform.
Methods: This is a prospective, non-randomized controlled trial evaluating the clinical and functional outcome in 29 patients with acute intra-cranial occlusions consequent to mechanical thrombectomy by the PS either as mono-therapy or as an adjunct to current standard of care. Patients were evaluated by a neurologist and treated by our in house interventional neuro-radiologists. Primary end-points were revascularization of the occluded target vessel to TIMI grade 2 or 3 and neurological outcome as measured by an improvement in the NIH Stroke Scale (NIHSS) score after the procedure.
Results: Complete revascularization (TIMI 3) was achieved in 21/29 (72.4%) of patients. Partial revascularization (TIMI 2) was established in 4/29 (13.8%) of patients. Revascularization failed in four (13.8%) patients. Nineteen (19) patients (65.5%) had at least a four-point improvement in NIHSS scores. Modified Rankin scale scores of ≤2 were seen in 37.9% of patients. There were no device-related adverse events. Symptomatic intra-cranial hemorrhage occurred in 7% of patients.
Conclusions: The PS has the potential of exercising a significant impact in the interventional treatment of ischaemic stroke in the future.