Effect of prothrombin 19911 A>G polymorphism on the risk of cerebral sinus-venous thrombosis
Article first published online: 28 JUN 2010
© 2010 The Author(s). European Journal of Neurology © 2010 EFNS
European Journal of Neurology
Volume 17, Issue 12, pages 1482–1485, December 2010
How to Cite
Martinelli, I., Bucciarelli, P., De Stefano, V., Passamonti, S. M., Menegatti, M., Tormene, D., Tosetto, A. and Mannucci, P. M. (2010), Effect of prothrombin 19911 A>G polymorphism on the risk of cerebral sinus-venous thrombosis. European Journal of Neurology, 17: 1482–1485. doi: 10.1111/j.1468-1331.2010.03068.x
- Issue published online: 18 NOV 2010
- Article first published online: 28 JUN 2010
- Received 26 January 2010 Accepted 25 March 2010
- cerebral vein thrombosis;
- factor V Leiden;
- prothrombin mutation;
- risk factors;
Background and Purpose: The A>G polymorphism at position 19911 of the prothrombin gene is associated with a mildly increased risk of venous thromboembolism, alone or in association with such common thrombophilia mutations as factor V Leiden and prothrombin 20210 GA. Its role in cerebral sinus-venous thrombosis (CSVT) is not known.
Methods: The presence of prothrombin 19911 A>G was investigated in a case–control study of 107 patients with cerebral thrombosis and factor V Leiden (n = 25), prothrombin 20210 GA (n = 47), without known thrombophilia (n = 35) and 842 healthy individuals with the corresponding coagulation profile.
Results: Prothrombin 19911 A>G did not increase the risk of CSVT in carriers of factor V Leiden (adjusted odds ratio 1.6, 95%CI 0.6–4.7), prothrombin 20210 GA (odds ratio 1.1, 95%CI 0.6–2.2), nor in patients without known thrombophilia (odds ratio 1.3, 95%CI 0.5–3.1).
Conclusions: Prothrombin 19911 A>G polymorphism does not appear to be a risk factor for CSVT, alone or in association with factor V Leiden or prothrombin 20210GA.