Genetic variation on chromosome 9p21 shows association with the ischaemic stroke subtype large-vessel disease in a Swedish sample aged ≤70
Article first published online: 25 MAY 2010
© 2010 The Author(s). European Journal of Neurology © 2010 EFNS
European Journal of Neurology
Volume 18, Issue 2, pages 365–367, February 2011
How to Cite
Olsson, S., Jood, K., Blomstrand, C. and Jern, C. (2011), Genetic variation on chromosome 9p21 shows association with the ischaemic stroke subtype large-vessel disease in a Swedish sample aged ≤70. European Journal of Neurology, 18: 365–367. doi: 10.1111/j.1468-1331.2010.03096.x
- Issue published online: 17 JAN 2011
- Article first published online: 25 MAY 2010
- Received 26 January 2010 Accepted 9 April 2010
- functional outcome;
- ischaemic stroke;
- single nucleotide polymorphism;
Background: The aim of this study was to investigate whether we could replicate a recent finding of an association between genetic variants on chromosome 9p21 and the ischaemic stroke (IS) subtype large-vessel disease (LVD).
Methods: The Sahlgrenska Academy Study on Ischemic Stroke comprises 844 patients with IS, who suffered IS before reaching the age of 70, and 668 healthy controls. IS subtype was defined according to the TOAST criteria, and 111 patients were categorized as LVD. Seven single-nucleotide polymorphisms (SNPs) on 9p21 were analyzed. Functional outcome was assessed 3 months after IS using the modified Rankin scale.
Results: The SNP rs7857345 showed a significant association with the subtype LVD independent of traditional vascular risk factors. In addition, an association between rs7857345 and functional outcome after LVD was observed.
Conclusion: In this relatively young sample of patients with IS, genetic variation on 9p21 is associated with LVD.