The first two authors contributed equally to the work.
Allergy and risk of glioma: a meta-analysis
Article first published online: 16 AUG 2010
© 2010 The Author(s). European Journal of Neurology © 2010 EFNS
European Journal of Neurology
Volume 18, Issue 3, pages 387–395, March 2011
How to Cite
Chen, C., Xu, T., Chen, J., Zhou, J., Yan, Y., Lu, Y. and Wu, S. (2011), Allergy and risk of glioma: a meta-analysis. European Journal of Neurology, 18: 387–395. doi: 10.1111/j.1468-1331.2010.03187.x
- Issue published online: 17 FEB 2011
- Article first published online: 16 AUG 2010
- Received 11 April 2010 Accepted 8 July 2010
- risk factor
We evaluated the association between allergic conditions and the risk of glioma in case–control and cohort studies published so far on this issue. A total of 12 studies (10 case–control and 2 cohort studies) were included in the analysis, involving 61 090 participants, of whom 6408 had glioma. When compared with non-allergic conditions, the pooled odds ratio (OR) with any allergic conditions for glioma was 0.60 (95% CI: 0.52–0.69, P < 0.001), suggesting a significant negative association (protective effect) between allergy and glioma. Subgroup analysis showed that the ORs were 0.70 (95% CI: 0.62–0.79, P < 0.001), 0.69 (95% CI: 0.62–0.78, P < 0.001), and 0.78 (95% CI: 0.70–0.87, P < 0.001) for asthma, eczema, and hay fever, respectively. The significant association remained even after excluding the bias of proxy reporting (OR = 0.61; 95% CI: 0.50–0.75, P < 0.001). We conclude that allergic conditions may significantly reduce the risk of glioma.