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Improved language performance subsequent to low-frequency rTMS in patients with chronic non-fluent aphasia post-stroke
Article first published online: 7 DEC 2010
© 2010 The Author(s). European Journal of Neurology © 2010 EFNS
European Journal of Neurology
Volume 18, Issue 7, pages 935–943, July 2011
How to Cite
Barwood, C. H. S., Murdoch, B. E., Whelan, B.-M., Lloyd, D., Riek, S., O’ Sullivan, J. D., Coulthard, A. and Wong, A. (2011), Improved language performance subsequent to low-frequency rTMS in patients with chronic non-fluent aphasia post-stroke. European Journal of Neurology, 18: 935–943. doi: 10.1111/j.1468-1331.2010.03284.x
- Issue published online: 9 JUN 2011
- Article first published online: 7 DEC 2010
- Received 7 August 2010 Accepted 28 October 2010
- stroke rehabilitation;
- transcranial magnetic stimulation (TMS)
Background: Low-frequency repetitive transcranial magnetic stimulation (rTMS) has emerged as a potential tool for neurorehabilitation and remediation of language in chronic non-fluent aphasia post-stroke. Inhibitory (1 Hz) rTMS has been applied to homologous language sites to facilitate behavioural language changes. Improvements in picture-naming performance and speech output over time have been reported.
Methods: Low-frequency (1 Hz) rTMS was applied to six real stimulation and six sham placebo patients for 20 min per day, for 10 days, and behavioural language outcome measures were taken at baseline (pre-stimulation) and 2 months post-stimulation.
Results: The findings demonstrate treatment-related changes observed in the stimulation group when compared to the placebo control group at 2 months post-stimulation on naming performance as well as other aspects of expressive language and auditory comprehension.
Conclusions: These findings provide considerable evidence to support the theory of rTMS modulating mechanisms of transcallosal disinhibition in the aphasic brain and highlight the potential clinical applications for language rehabilitation post-stroke.