Oro-buccal symptoms (dysphagia, dysarthria, and sialorrhea) in patients with Parkinson’s disease: preliminary analysis from the French COPARK cohort

  1. S. Perez-Lloret1,2,3,
  2. L. Nègre-Pagès1,2,4,
  3. A. Ojero-Senard1,2,
  4. P. Damier5,
  5. A. Destée6,
  6. F. Tison7,
  7. M. Merello3,
  8. O. Rascol1,2,
  9. for the COPARK Study Group

Article first published online: 1 APR 2011

DOI: 10.1111/j.1468-1331.2011.03402.x

Issue

European Journal of Neurology

European Journal of Neurology

Volume 19, Issue 1, pages 28–37, January 2012

Additional Information

How to Cite

Perez-Lloret, S., Nègre-Pagès, L., Ojero-Senard, A., Damier, P., Destée, A., Tison, F., Merello, M., Rascol, O. and for the COPARK Study Group (2012), Oro-buccal symptoms (dysphagia, dysarthria, and sialorrhea) in patients with Parkinson’s disease: preliminary analysis from the French COPARK cohort. European Journal of Neurology, 19: 28–37. doi: 10.1111/j.1468-1331.2011.03402.x

Author Information

  1. 1

    Departments of Clinical Pharmacology and Neurosciences, University Hospital and University of Toulouse, Toulouse

  2. 2

    INSERM CIC-9023 and UMR-825, Toulouse, France

  3. 3

    Movement Disorders Section, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina

  4. 4

    LN-Pharma, Toulouse

  5. 5

    CHU Nantes, CIC 04, Pôle neurosciences, Nantes

  6. 6

    Service de neurologie et pathologie du mouvement, Pôle de neurologie, Centre hospitalier universitaire, Lille

  7. 7

    Service de neurologie, Groupe Hospitalier Sud, Hôpital Haut-Lévèque, CHU de Bordeaux, France

*Professor O. Rascol, Department of Clinical Pharmacology, Faculty of Medicine, 37 Allées Jules Guesde, 31000 Toulouse, France (tel.: +33 5 61 14 59 62; fax: +33 5 61 14 56 42; e-mail: rascol@cict.fr).

Publication History

  1. Issue published online: 19 DEC 2011
  2. Article first published online: 1 APR 2011
  3. Received 13 October 2010 Accepted 3 March 2011

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Keywords:

  • Parkinson’s disease;
  • dysarthria;
  • sialorrhea;
  • dysphagia;
  • non-motor symptoms

Introduction:  Abnormal oro-buccal functions including dysarthria, sialorrhea and dysphagia commonly affect patients with Parkinson’s disease (PD).

Objectives:  To estimate the prevalence of such oro-buccal symptoms at baseline in the first 419 patients with PD included in the COPARK cohort and to analyze their correlations with patients’ demographics, clinical characteristics, and drugs consumption.

Methods:  Patients were assessed using the Unified PD Rating Scale, the Hospital Anxiety and Depression Scale, and the PDQ-39. Dysarthria, sialorrhea, and dysphagia were defined as UPDRS items 5, 6, or 7 ≥ 1.

Results:  Dysarthria, sialorrhea, or dysphagia were present in 51%, 37%, or 18% out of the 419 patients, respectively. At least one of these symptom was present in 267/419 patients (65%), whilst a combination of symptoms was present in 136/419 (33%). Logistic regression showed that the presence of each of the three oro-buccal symptoms was significantly correlated with that of the two others. Other correlations included male gender, hallucinations, disease severity, levodopa use and lack of opiates consumption for dysarthria; disease severity, orthostatic hypotension and absence of antidepressants consumption for sialorrhea; female gender, motor fluctuations, and depressive symptoms for dysphagia. None of the three oro-buccal symptoms were associated with a reduced PDQ-39 score.

Conclusion:  Oro-buccal symptoms were present in two of three patients with moderate PD, the presence of each symptoms being significantly correlated with that of the two others.

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