Oro-buccal symptoms (dysphagia, dysarthria, and sialorrhea) in patients with Parkinson’s disease: preliminary analysis from the French COPARK cohort

Authors

  • S. Perez-Lloret,

    1. Departments of Clinical Pharmacology and Neurosciences, University Hospital and University of Toulouse, Toulouse
    2. INSERM CIC-9023 and UMR-825, Toulouse, France
    3. Movement Disorders Section, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina
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  • L. Nègre-Pagès,

    1. Departments of Clinical Pharmacology and Neurosciences, University Hospital and University of Toulouse, Toulouse
    2. INSERM CIC-9023 and UMR-825, Toulouse, France
    3. LN-Pharma, Toulouse
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  • A. Ojero-Senard,

    1. Departments of Clinical Pharmacology and Neurosciences, University Hospital and University of Toulouse, Toulouse
    2. INSERM CIC-9023 and UMR-825, Toulouse, France
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  • P. Damier,

    1. CHU Nantes, CIC 04, Pôle neurosciences, Nantes
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  • A. Destée,

    1. Service de neurologie et pathologie du mouvement, Pôle de neurologie, Centre hospitalier universitaire, Lille
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  • F. Tison,

    1. Service de neurologie, Groupe Hospitalier Sud, Hôpital Haut-Lévèque, CHU de Bordeaux, France
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  • M. Merello,

    1. Movement Disorders Section, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina
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  • O. Rascol,

    1. Departments of Clinical Pharmacology and Neurosciences, University Hospital and University of Toulouse, Toulouse
    2. INSERM CIC-9023 and UMR-825, Toulouse, France
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  • for the COPARK Study Group


Professor O. Rascol, Department of Clinical Pharmacology, Faculty of Medicine, 37 Allées Jules Guesde, 31000 Toulouse, France (tel.: +33 5 61 14 59 62; fax: +33 5 61 14 56 42; e-mail: rascol@cict.fr).

Abstract

Introduction:  Abnormal oro-buccal functions including dysarthria, sialorrhea and dysphagia commonly affect patients with Parkinson’s disease (PD).

Objectives:  To estimate the prevalence of such oro-buccal symptoms at baseline in the first 419 patients with PD included in the COPARK cohort and to analyze their correlations with patients’ demographics, clinical characteristics, and drugs consumption.

Methods:  Patients were assessed using the Unified PD Rating Scale, the Hospital Anxiety and Depression Scale, and the PDQ-39. Dysarthria, sialorrhea, and dysphagia were defined as UPDRS items 5, 6, or 7 ≥ 1.

Results:  Dysarthria, sialorrhea, or dysphagia were present in 51%, 37%, or 18% out of the 419 patients, respectively. At least one of these symptom was present in 267/419 patients (65%), whilst a combination of symptoms was present in 136/419 (33%). Logistic regression showed that the presence of each of the three oro-buccal symptoms was significantly correlated with that of the two others. Other correlations included male gender, hallucinations, disease severity, levodopa use and lack of opiates consumption for dysarthria; disease severity, orthostatic hypotension and absence of antidepressants consumption for sialorrhea; female gender, motor fluctuations, and depressive symptoms for dysphagia. None of the three oro-buccal symptoms were associated with a reduced PDQ-39 score.

Conclusion:  Oro-buccal symptoms were present in two of three patients with moderate PD, the presence of each symptoms being significantly correlated with that of the two others.

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