Prevention of post-stroke cognitive decline: a review focusing on lifestyle interventions
Article first published online: 4 JUN 2012
© 2012 The Author(s) European Journal of Neurology © 2012 EFNS
European Journal of Neurology
Volume 20, Issue 1, pages 35–49, January 2013
How to Cite
Teuschl, Y., Matz, K. and Brainin, M. (2013), Prevention of post-stroke cognitive decline: a review focusing on lifestyle interventions. European Journal of Neurology, 20: 35–49. doi: 10.1111/j.1468-1331.2012.03757.x
- Issue published online: 22 DEC 2012
- Article first published online: 4 JUN 2012
- Manuscript Accepted: 19 APR 2012
- Manuscript Received: 17 FEB 2012
- ischaemic stroke;
- mild vascular cognitive impairment;
- multiple risk factor intervention;
- post-stroke dementia;
- risk factor
Background and purpose
Despite a high prevalence of post-stroke cognitive impairment, therapeutic possibilities are still limited. Stroke and dementia share the same cluster of modifiable risk factors. Thus, lifestyle interventions and strict adherence to medication may not only decrease the risk of recurrent stroke but also the risk of post-stroke cognitive decline.
We performed a systematic literature search for randomized clinical trials (RCTs) targeting modifiable risk factors for the prevention of cognitive decline following stroke.
We identified 25 non-pharmacological interventions and eight multiple risk factor interventions in stroke patients using cognition as outcome measure. None of the published trials investigated interventions aimed at the prevention of post-stroke cognitive decline. However, a number of ongoing trials aim at risk factor reduction and include measures on cognition.
Evidence for risk factor modification for the prevention of cognitive decline after stroke is scarce and comes mainly from observational studies. There is a need for more RCTs targeting the prevention of post-stroke dementia using lifestyle interventions and a multiple risk factor approach.