See editorial by Lahiri and Ray on page 211.
Soluble amyloid precursor protein α in the cerebrospinal fluid as a diagnostic and prognostic biomarker for idiopathic normal pressure hydrocephalus
Article first published online: 4 JUN 2012
© 2012 The Author(s) European Journal of Neurology © 2012 EFNS
European Journal of Neurology
Volume 20, Issue 2, pages 236–242, February 2013
How to Cite
Miyajima, M., Nakajima, M., Ogino, I., Miyata, H., Motoi, Y. and Arai, H. (2013), Soluble amyloid precursor protein α in the cerebrospinal fluid as a diagnostic and prognostic biomarker for idiopathic normal pressure hydrocephalus. European Journal of Neurology, 20: 236–242. doi: 10.1111/j.1468-1331.2012.03781.x
- Issue published online: 12 JAN 2013
- Article first published online: 4 JUN 2012
- Manuscript Accepted: 24 APR 2012
- Manuscript Received: 29 FEB 2012
- Ministry of Health, Labor and Welfare of Japan. Grant Number: 2011-Nanchi-018
- Juntendo University Research Institute for Diseases and Old Age
- cerebrospinal fluid;
- idiopathic normal pressure hydrocephalus;
- soluble amyloid precursor protein
Cognitive impairment is difficult to improve after shunt operation in patients with idiopathic normal pressure hydrocephalus (iNPH). This study aims to identify cerebrospinal fluid (CSF) biomarkers predictive of improvement in cognitive function.
This study was conducted between January 2008 and December 2010 on consecutive, unselected admissions to our program for the treatment of patients with clinically suspected iNPH. Lumbar CSF concentrations of total tau (Tau), tau phosphorylated at threonine 181 (p-tau), soluble amyloid precursor protein (sAPP), sAPPα, sAPPβ, and β-amyloid1-42 (Aβ42) were analyzed by ELISA.
Concentrations of p-tau, sAPP, sAPPα, and sAPPβ were strong diagnostic biomarkers for distinguishing between iNPH and Alzheimer's disease (AD). sAPPα exhibited the highest accuracy in differentiating iNPH from patients with AD and normal controls, with an area under the curve value of 0.994. We examined the prognostic value of p-tau and sAPPα for cognition function after surgery. With a cutoff value of 198 ng/ml or less for sAPPα, sensitivity and specificity are 66.7% and 82.9%, respectively, whilst the Mini-Mental State Examination score at 6 months after surgery is expected to be 25 or more.
Our results show that sAPPα is a suitable biomarker for the diagnosis and prognosis of iNPH.