Biomarkers and functional outcomes from ischaemic cerebral events in women: a prospective cohort study
Article first published online: 3 OCT 2012
© 2012 The Author(s) European Journal of Neurology © 2012 EFNS
European Journal of Neurology
Volume 20, Issue 2, pages 375–381, February 2013
How to Cite
Rist, P. M., Buring, J. E., Kase, C. S., Ridker, P. M. and Kurth, T. (2013), Biomarkers and functional outcomes from ischaemic cerebral events in women: a prospective cohort study. European Journal of Neurology, 20: 375–381. doi: 10.1111/j.1468-1331.2012.03874.x
- Issue published online: 12 JAN 2013
- Article first published online: 3 OCT 2012
- Manuscript Accepted: 17 AUG 2012
- Manuscript Received: 15 MAY 2012
- National Institutes of Health
- HL-043851. Grant Numbers: HL-080467, HL-099355, CA-047988
- Donald W. Reynolds Foundation
- Leducq Foundation
- Doris Duke Charitable Foundation
- National Institute of Aging. Grant Number: AG-00158
Background and purpose
Several biomarkers have been associated with an increased risk of ischaemic stroke. However, the association between these biomarkers and functional outcome from cerebral ischaemic events is unclear. We aimed to assess the patterns of association between cardiovascular disease biomarkers and functional outcomes after incident ischaemic cerebral events in women.
Prospective cohort study of 27 728 women enrolled in the Women's Health Study who provided information on blood samples and were free of stroke or transient ischaemic attack (TIA) at baseline. Multinomial logistic regression was used to determine the association between elevated biomarker levels and functional outcomes from ischaemic cerebral events. Possible functional outcomes included TIA and ischaemic stroke with modified Rankin Scale (mRS) score of 0–1, 2–3, or 4–6.
After a mean follow-up of 15.1 years, 461 TIAs and 380 ischaemic strokes occurred. Elevated levels of total cholesterol were associated with the highest risk of poor functional outcome (mRS 4–6) after incident cerebral ischaemic events (relative risk = 2.02, 95% CI = 1.18–3.46). We observed significant associations between elevated levels of total cholesterol, Lp(a), C-reactive protein, and triglycerides, and mild or moderate functional outcomes after ischaemic cerebral events. Elevations in all other biomarkers were not significantly associated with functional outcomes.
Whilst total cholesterol level was associated with highest risks of poor functional outcome after stroke, we overall observed an inconsistent pattern of association between biomarkers linked with an increased risk of vascular events and more impaired functional outcomes from stroke.